Trekrezan and Polyoxidonium in experimental bronchopulmonary inflammation
I. V. Zarubina, A. V. Bolekhan, P. D. Shabanov · 2006 · Experimental and Clinical Pharmacology. 2006;69(5):50–54. PMID 17153967.
Indexed 2026-11-11.
Reported findings and study design
Narrative findings; numerical extraction incomplete
The abstract describes a tracheal turpentine model, comparing Trekrezan 25 mg/kg with Polyoxidonium 0.75 mg/kg. It omits the drug administration route and timing.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Lymphocyte and lung metabolites | Lower lactate, ADP and AMP; higher pyruvate and ATP with both drugs | |
| Tissue-dependent response | Polyoxidonium’s metabolic response was more pronounced in lung tissue | Qualitative description. The abstract describes a stronger general metabolic effect with Trekrezan. |
| Lymphocyte immune status | Improvement described with both drugs | No effect sizes in the abstract. |
Source for these results ↗ · Reviewed 2026-11-11
For research and education. Consult a qualified clinician for medical advice.
Study limitations and source details
Study limitations
- The abstract gives no group sizes, route, schedule, numerical endpoint estimates or safety results.
- The publication and Bolekhan’s dissertation involve the same research group and model. Independence is unverified.
Source access
Original indexed abstract checked.
Source reviewed 2026-11-11.
Citation and original source
Original source: I. V. Zarubina, A. V. Bolekhan, P. D. Shabanov. Trekrezan and Polyoxidonium in experimental bronchopulmonary inflammation Experimental and Clinical Pharmacology. 2006;69(5):50–54. PMID 17153967. 2006.
Molekul research summary: https://molekul.io/research/zarubina-trekrezan-polyoxidonium-2006. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entryRelated compound profiles
Trekrezan
A research lineage linking synthetic adaptogen chemistry with Kirov environmental-stress and immune-metabolism programs. Human cold-exposure work, animal hypoxia studies and experimental combinations are distinguished below.
Polyoxidonium
Azoximer bromide is a synthetic polymer studied alongside Trekrezan and Bemitil in rat inflammation models and isolated macrophage assays.