Semax during repeated rotarod testing in rats
N. N. Karkishchenko, V. V. Uyba, V. N. Karkishchenko, E. B. Shustov, K. V. Kotenko, S. L. Lyublinskiy · 2014 · Essays on Sports Pharmacology, Vol. III, Vectors of Pharmacoregulation, Chapter 5, pp. 145–147, Figures 54–55
Indexed 2026-11-09.
Related evidence maps: Sports performance ↗
Reported findings and study design
The authors reported a 263% increase in duration on day 21 relative to day 7. They classified the effect on fatigue resistance as a statistical trend.
Accelerating rotarod, assessed weekly during dosing and again seven days after the course.
Dose, route and schedule
Semax 0.22 mg/kg rectally daily for 21 days.
Protocol source ↗ · Original publication and selected methods and results checked
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Rotarod duration | +263% at day 21 relative to day 7 | Duration dropped after dosing stopped. Controls showed smaller gains with repeated testing. · Authors described a trend around p=0.1 |
Keep the within-group percentage and weak statistical result together.
Source for the extracted data ↗ · Checked 2026-11-09
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Repeated training, coordination and motivation can affect the endpoint. The graph does not supply a confirmed human effect.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Original publication and selected methods and results checked
Review depth: Reported methods, results and evidence limitations
Source access and review scope
Original publication and selected methods and results checked
Recorded source-check date: 2026-11-09. This date does not imply a completed systematic review.
Source type: Essays on Sports Pharmacology, Vol. III, Vectors of Pharmacoregulation, Chapter 5, pp. 145–147, Figures 54–55
Citation and original source
Original source: N. N. Karkishchenko, V. V. Uyba, V. N. Karkishchenko, E. B. Shustov, K. V. Kotenko, S. L. Lyublinskiy. Semax during repeated rotarod testing in rats Essays on Sports Pharmacology, Vol. III, Vectors of Pharmacoregulation, Chapter 5, pp. 145–147, Figures 54–55 2014.
Molekul research summary: https://molekul.io/research/shustov-volume3-semax-rotarod-2014. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry