Pept-5 through Pept-11 in a rat hypobaric hypoxia experiment
Kh. Kh. Semenov, N. N. Karkishchenko, V. N. Karkishchenko, G. D. Kapanadze, O. I. Stepanova, L. Kh. Kazakova, A. O. Revyakin, N. V. Kasinskaya, E. L. Matveenko, S. E. Dengina, Yu. V. Fokin · 2012 · Biomeditsina. 2012;(4):45–48.
Indexed 2026-11-11.
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Reported findings and study design
Reported findings
Investigators measured time to agonal breathing during simulated altitude exposure at baseline and on days 7, 14, 21 and 28. Administration ended on day 21. First collapse and time to regain posture were also defined in the methods.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Pept-8 time to agonal breathing | 252 → 627 → 570 seconds | Baseline, day 21 and day 28. Day 21 was about 2.49× the reported baseline. |
| Pept-10 time to agonal breathing | 323 → 897 → 1,047 seconds | Baseline, day 21 and day 28. |
| Pept-11 time to agonal breathing | 226 → 770 → 1,003 seconds | Baseline, day 21 and day 28. |
Mean time to agonal breathing in the seven coded arms
| Preparation | Baseline (s) | Day 7 (s) | Day 14 (s) | Day 21 (s) | Day 28 (s) |
|---|---|---|---|---|---|
| Pept-5 | 380 | 494 | 590 | 728 | 487 |
| Pept-6 | 398 | 517 | 655 | 720 | 665 |
| Pept-7 | 453 | 557 | 665 | 703 | 632 |
| Pept-8 | 252 | 398 | 485 | 627 | 570 |
| Pept-9 | 216 | 485 | 593 | 702 | 570 |
| Pept-10 | 323 | 632 | 795 | 897 | 1,047 |
| Pept-11 | 226 | 550 | 682 | 770 | 1,003 |
The article gives no matching control time series in this table. Day 28 was seven days after administration stopped.
Baseline-relative changes cannot isolate an effect from repeated exposure or other time-dependent changes. No human outcomes were measured.
Source for these results ↗ · Reviewed 2026-11-11
For research and education. Consult a qualified clinician for medical advice.
Study limitations and source details
Study limitations
- The table reports means for treated groups and their own starting values. It supplies no day-by-day control series, dispersion estimates or treatment-versus-control tests.
- The prose groups Pept-10 with preparations exceeding threefold at day 21. Its table gives 897/323 seconds, or about 2.8-fold.
- The preparation code does not identify an amino-acid sequence or establish correspondence with the 2013 Pep series, VIR-8 or the patented brain fractions.
Source access
Original article’s indexed Russian transcription and numerical results table checked. Publisher issue PDF unavailable during this review.
Source reviewed 2026-11-11.
Citation and original source
Original source: Kh. Kh. Semenov, N. N. Karkishchenko, V. N. Karkishchenko, G. D. Kapanadze, O. I. Stepanova, L. Kh. Kazakova, A. O. Revyakin, N. V. Kasinskaya, E. L. Matveenko, S. E. Dengina, Yu. V. Fokin. Pept-5 through Pept-11 in a rat hypobaric hypoxia experiment Biomeditsina. 2012;(4):45–48. 2012.
Molekul research summary: https://molekul.io/research/semenov-pept-hypoxia-2012. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry