COMPOUND RECORD / PEPT-8

Pept-8 (2012 series)Пепт-8

PerformanceStress

Source linked

What the studies found

Animal research · 2012

Pept-5 through Pept-11 in a rat hypobaric hypoxia experiment

Pept-8 time to agonal breathing: 252 → 627 → 570 secondsBaseline, day 21 and day 28. Day 21 was about 2.49× the reported baseline.
Pept-10 time to agonal breathing: 323 → 897 → 1,047 secondsBaseline, day 21 and day 28.
Pept-11 time to agonal breathing: 226 → 770 → 1,003 secondsBaseline, day 21 and day 28.

Time to agonal breathing with Pept-8 rose from 252 seconds at baseline to 627 seconds on day 21 and was 570 seconds on day 28. Pept-10 and Pept-11 had their longest measured times on day 28.

Study notes · methods, sources and limitations

Participants or model Wistar rats exposed to acute hypobaric hypoxia.

Design Investigators measured time to agonal breathing during simulated altitude exposure at baseline and on days 7, 14, 21 and 28. Administration ended on day 21. First collapse and time to regain posture were also defined in the methods.

Important limitations

The table reports means for treated groups and their own starting values. It supplies no day-by-day control series, dispersion estimates or treatment-versus-control tests. The prose groups Pept-10 with preparations exceeding threefold at day 21. Its table gives 897/323 seconds, or about 2.8-fold. The preparation code does not identify an amino-acid sequence or establish correspondence with the 2013 Pep series, VIR-8 or the patented brain fractions.
Baseline-relative changes cannot isolate an effect from repeated exposure or other time-dependent changes. No human outcomes were measured.

Biomeditsina. 2012;(4):45–48. · Publication record

Original source or citation ↗

Study results and tables ↗

01 / OVERVIEW

About Pept-8 (2012 series)

Names in this research collection

Pept 8 · Pept-5–11 series

A coded preparation in the 2012 Pept-5 through Pept-11 rat hypoxia series. The paper describes 5–18 kDa animal-derived peptide and protein mixtures. Its sequence and relationship to the later Pep-8 and VIR-8 preparations remain unknown.

Research background

Performance research in context

Military & occupational evidence map ↗

Compound class: Coded animal-derived peptide preparation
Research collection: Actoprotection & occupational pharmacology · editorial grouping
Research institutions: No institutional affiliation recorded
Source review: Review dates and the material assessed are listed with each publication below.

02 / HOW TO READ THE RESEARCH

Understanding the evidence

Human research Rat hypoxia study
Study methods Repeated simulated altitude exposure and timed respiratory endpoint
Independent replication Independent replication unresolved
Source access Original article transcription and table
Safety evidence Human safety unavailable

Open a topic for the evidence assessment.

More findings, background and history

What remains unclear

The available experimental studies leave human benefit and safety uncertain.

No human intervention report has been identified among the linked records; unclassified archival leads may remain. Several publications can describe the same participants.

Browse original study records ↗

03 / SOURCE RECORDS

Linked sources

Explore the research map and unresolved leads ↗

2012 · Pept-5 through Pept-11 in a rat hypobaric hypoxia experimentPept-8 time to agonal breathing: 252 → 627 → 570 seconds

2012Animal / experimentalRussian source · see review scope

Pept-5 through Pept-11 in a rat hypobaric hypoxia experiment

Coded animal-derived peptide and protein mixtures in the reported 5–18 kDa range

Kh. Kh. Semenov, N. N. Karkishchenko, V. N. Karkishchenko, G. D. Kapanadze, O. I. Stepanova, L. Kh. Kazakova, A. O. Revyakin, N. V. Kasinskaya, E. L. Matveenko, S. E. Dengina, Yu. V. Fokin · Biomeditsina. 2012;(4):45–48.

Time to agonal breathing with Pept-8 rose from 252 seconds at baseline to 627 seconds on day 21 and was 570 seconds on day 28. Pept-10 and Pept-11 had their longest measured times on day 28.

Results and tables

Reported findings and study design

Reported findings

Investigators measured time to agonal breathing during simulated altitude exposure at baseline and on days 7, 14, 21 and 28. Administration ended on day 21. First collapse and time to regain posture were also defined in the methods.

Results · Original article’s indexed Russian transcription and numerical results table checked. Publisher issue PDF unavailable during this review.
Measure	Result	Comparison, timing and statistics
Pept-8 time to agonal breathing	252 → 627 → 570 seconds	Baseline, day 21 and day 28. Day 21 was about 2.49× the reported baseline.
Pept-10 time to agonal breathing	323 → 897 → 1,047 seconds	Baseline, day 21 and day 28.
Pept-11 time to agonal breathing	226 → 770 → 1,003 seconds	Baseline, day 21 and day 28.

Mean time to agonal breathing in the seven coded arms

Mean time to agonal breathing in the seven coded arms
Preparation	Baseline (s)	Day 7 (s)	Day 14 (s)	Day 21 (s)	Day 28 (s)
Pept-5	380	494	590	728	487
Pept-6	398	517	655	720	665
Pept-7	453	557	665	703	632
Pept-8	252	398	485	627	570
Pept-9	216	485	593	702	570
Pept-10	323	632	795	897	1,047
Pept-11	226	550	682	770	1,003

The article gives no matching control time series in this table. Day 28 was seven days after administration stopped.

Baseline-relative changes cannot isolate an effect from repeated exposure or other time-dependent changes. No human outcomes were measured.

Source for these results ↗ · Reviewed 2026-11-11

Population / setting: Wistar rats exposed to acute hypobaric hypoxia.
Source reviewed: Original article’s indexed Russian transcription and numerical results table checked. Publisher issue PDF unavailable during this review.

Study limitations

The table reports means for treated groups and their own starting values. It supplies no day-by-day control series, dispersion estimates or treatment-versus-control tests.
The prose groups Pept-10 with preparations exceeding threefold at day 21. Its table gives 897/323 seconds, or about 2.8-fold.
The preparation code does not identify an amino-acid sequence or establish correspondence with the 2013 Pep series, VIR-8 or the patented brain fractions.

Reviewed 2026-11-11.

Read the source ↗

Follow shared publications or research classes. These links do not establish equivalent effects between compounds.