Radiolabeled Semax in rat brain after intranasal dosing
K. V. Shevchenko, I. Yu. Nagaev, L. Yu. Alfeeva, L. A. Andreeva, A. A. Kamensky, N. G. Levitskaya, V. P. Shevchenko, I. A. Grivennikov, N. F. Myasoedov · 2006 · Bioorganicheskaya Khimiya, PMID 16523722
Indexed 2026-11-09.
Related evidence maps: Military & occupational research ↗
Reported findings and study design
At two minutes, 0.093% of administered radioactivity per gram was detected in brain. About 80% of that signal was identified as Semax.
Tritium label on C-terminal proline, with measurements of Semax and degradation products in blood and brain.
Dose, route and schedule
Single intranasal dose of 50 µg/kg, 20 µL solution.
Protocol source ↗ · Bioorganicheskaya Khimiya, PMID 16523722
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Brain signal at two minutes | 0.093% of administered radioactivity per gram | Approximately 80% intact Semax and the remainder metabolites. |
| Biotransformation | Rapid degradation; Pro–Gly–Pro predominated among peptide products | Neither target-site concentration nor a human half-life is supplied. |
Rat tissue radioactivity does not resolve the transport path, blood contribution or human pharmacokinetics.
Source for the extracted data ↗ · Checked 2026-11-09
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Rat tissue radioactivity does not resolve the transport path, blood contribution or human pharmacokinetics.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Bioorganicheskaya Khimiya, PMID 16523722
Review depth: Reported methods, results and evidence limitations
Source access and review scope
Bioorganicheskaya Khimiya, PMID 16523722
Recorded source-check date: 2026-11-09. This date does not imply a completed systematic review.
Source type: Bioorganicheskaya Khimiya, PMID 16523722
Citation and original source
Original source: K. V. Shevchenko, I. Yu. Nagaev, L. Yu. Alfeeva, L. A. Andreeva, A. A. Kamensky, N. G. Levitskaya, V. P. Shevchenko, I. A. Grivennikov, N. F. Myasoedov. Radiolabeled Semax in rat brain after intranasal dosing Bioorganicheskaya Khimiya, PMID 16523722 2006.
Molekul research summary: https://molekul.io/research/semax-shevchenko-nasal-pk-2006. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry