The Effect of Peptide Semax, an ACTH(4-10) Analogue, on Intracellular Calcium Dynamics in Rat Brain Neurons.
Kolbaev SN, Sharonova IN, Skrebitsky VG · 2025 · Bulletin of experimental biology and medicine; 2025 Aug
Study findings
Semax increased spontaneous calcium-event frequency in hippocampal CA1 neurons. It did not significantly change proton-stimulated calcium responses in cerebellar granule cells.
- Population and setting
- Rat brain neurons and brain-slice preparations
- Evidence type
- In vitro
- Preparation
- See the original report; formulation details require verification.
- Source language
- eng
- Title source
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
Study limitations
- Cellular calcium signals are not clinical cognitive outcomes.
- The negative proton-response finding does not support the proposed acid-sensing-channel effect in this assay.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Source access and review scope
Indexed record and abstract checked. Full methods and risk of bias have not been independently assessed.
Recorded source-check date: 2026-10-06. This date does not imply a completed systematic review.
Citation and original source
Original source: Kolbaev SN, Sharonova IN, Skrebitsky VG. The Effect of Peptide Semax, an ACTH(4-10) Analogue, on Intracellular Calcium Dynamics in Rat Brain Neurons. Bulletin of experimental biology and medicine; 2025 Aug 2025.
Molekul research summary: https://molekul.io/research/recent-41171324. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry