Genes That Associated with Action of ACTH-like Peptides with Neuroprotective Potential in Rat Brain Regions with Different Degrees of Ischemic Damage.
Filippenkov IB, Shpetko YY, Ales DA, Stavchansky VV, Denisova AE, Yuzhakov VV, Fomina NK, Gubsky LV, Andreeva LA, Myasoedov NF, Limborska SA, Dergunova LV · 2025 · International journal of molecular sciences; 2025 Jun
Study findings
Semax partially countered ischemia-associated gene-expression changes in the striatum. The response was smaller than previously reported in the frontal cortex.
- Population and setting
- Rat striatum, 24 hours after transient middle cerebral artery occlusion
- Evidence type
- Animal / experimental
- Preparation
- See the original report; formulation details require verification.
- Source language
- eng
- Title source
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
Study limitations
- Uses the same animals as the 2024 frontal-cortex paper; not independent replication.
- The reported worsening of 152 inflammation-associated genes concerned ACTH(6–9)PGP, not Semax.
- Transcriptomic changes do not establish human stroke recovery.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Related-report group: semax-tmcao-frontal-striatum-2024-2025. Reports in this group are not assumed to be independent trials.
Source access and review scope
Indexed record and abstract checked. Full methods and risk of bias have not been independently assessed. Open full text: https://pmc.ncbi.nlm.nih.gov/articles/PMC12249733/
Recorded source-check date: 2026-10-06. This date does not imply a completed systematic review.
Open original source or index record ↗
DOI: 10.3390/ijms26136256
Citation and original source
Original source: Filippenkov IB, Shpetko YY, Ales DA, Stavchansky VV, Denisova AE, Yuzhakov VV, Fomina NK, Gubsky LV, Andreeva LA, Myasoedov NF, Limborska SA, Dergunova LV. Genes That Associated with Action of ACTH-like Peptides with Neuroprotective Potential in Rat Brain Regions with Different Degrees of Ischemic Damage. International journal of molecular sciences; 2025 Jun 2025.
Molekul research summary: https://molekul.io/research/recent-40650034. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry