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Semax, a Copper Chelator Peptide, Decreases the Cu(II)-Catalyzed ROS Production and Cytotoxicity of aβ by Metal Ion Stripping and Redox Silencing.

Tomasello MF, Di Rosa MC, Naletova I, Sciacca MFM, Giuffrida A, Maccarrone G, Attanasio F · 2025 · Bioinorganic chemistry and applications; 2025

In vitroFull text availableSource linked

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Study findings

Semax reduced copper-associated reactive oxygen species and amyloid-related cellular toxicity in the tested systems, consistent with copper binding and altered redox activity.

Population and setting: Copper–amyloid chemistry and SH-SY5Y cell experiments
Evidence type: In vitro
Preparation: See the original report; formulation details require verification.
Source language: eng
Title source: Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.

Study limitations

Chemical and cell assays do not demonstrate Alzheimer’s treatment efficacy.
Effective brain exposure and clinical safety were not established.

Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.

Source access and review scope

Indexed record and abstract checked. Full methods and risk of bias have not been independently assessed. Open full text: https://pmc.ncbi.nlm.nih.gov/articles/PMC12151629/

Recorded source-check date: 2026-10-06. This date does not imply a completed systematic review.

Open original source or index record ↗

DOI: 10.1155/bca/4226220

Citation and original source

Original source: Tomasello MF, Di Rosa MC, Naletova I, Sciacca MFM, Giuffrida A, Maccarrone G, Attanasio F. Semax, a Copper Chelator Peptide, Decreases the Cu(II)-Catalyzed ROS Production and Cytotoxicity of aβ by Metal Ion Stripping and Redox Silencing. Bioinorganic chemistry and applications; 2025 2025.

Molekul research summary: https://molekul.io/research/recent-40496623. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.

Bibliography entry

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