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ACTH-like Peptides Compensate Rat Brain Gene Expression Profile Disrupted by Ischemia a Day After Experimental Stroke.

Filippenkov IB, Shpetko YY, Stavchansky VV, Denisova AE, Gubsky LV, Andreeva LA, Myasoedov NF, Limborska SA, Dergunova LV · 2024 · Biomedicines; 2024 Dec

Animal / experimentalFull text availableSource linked

This is Molekul’s research summary, not the original publication. Educational information only, not medical advice. Seek qualified healthcare help for medical conditions.

Study findings

Semax and ACTH(6–9)PGP partly countered ischemia-associated gene-expression changes involving neurotransmission and inflammation.

Population and setting: Rat frontal cortex, 24 hours after transient middle cerebral artery occlusion
Evidence type: Animal / experimental
Preparation: See the original report; formulation details require verification.
Source language: eng
Title source: Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.

Study limitations

The 2025 striatal analysis used these same animals.
Different peptides and brain regions must be distinguished.
Gene-expression endpoints do not establish patient benefit.

Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.

Related-report group: semax-tmcao-frontal-striatum-2024-2025. Reports in this group are not assumed to be independent trials.

Source access and review scope

Indexed record and abstract checked. Full methods and risk of bias have not been independently assessed. Open full text: https://pmc.ncbi.nlm.nih.gov/articles/PMC11673339/

Recorded source-check date: 2026-10-06. This date does not imply a completed systematic review.

Open original source or index record ↗

DOI: 10.3390/biomedicines12122830

Citation and original source

Original source: Filippenkov IB, Shpetko YY, Stavchansky VV, Denisova AE, Gubsky LV, Andreeva LA, Myasoedov NF, Limborska SA, Dergunova LV. ACTH-like Peptides Compensate Rat Brain Gene Expression Profile Disrupted by Ischemia a Day After Experimental Stroke. Biomedicines; 2024 Dec 2024.

Molekul research summary: https://molekul.io/research/recent-39767736. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.

Bibliography entry

Related compound profiles

Semax

ACTH-fragment-derived peptide with clinical stroke and optic-nerve reports, healthy-volunteer imaging and preclinical neuroregulation research. Precursor, patent and dissertation sources remain separately labeled.

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