PPC-M bovine brain complex: analytical and rat histology study
V. P. Yamskova, M. S. Krasnov, P. A. Yelistratov, V. M. Chekova, E. V. Sidorskii, A. P. Ilina · 2026 · Original article, sections 2.13 and 3; DOI 10.60797/IRJ.2026.164.62
Indexed 2026-11-09.
Related evidence maps: Military & occupational ↗
Reported findings and study design
PPC-M contained polypeptides in the 2,180–7,755 Da range and an albumin-like protein. Rat brain histology was described qualitatively.
MALDI-TOF and N-terminal sequencing, spectroscopy, protein aggregation assays and histology after experimental intracerebral hemorrhage.
Dose, route and schedule
Daily intranasal 20 µL per nostril of saline or PPC-M at the printed concentration of 10⁻¹² mg protein/mL.
Protocol source ↗ · Original article, sections 2.13 and 3; DOI 10.60797/IRJ.2026.164.62
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Fraction 3H peptide masses | 2,180–7,755 Da | Main text; conclusion prints 7,715 Da. Overlap by size with other extracts does not identify shared sequences. |
| Albumin-like component | Approximately 66.7 kDa | N-terminal sequence was consistent with bovine serum albumin. |
| Histological observations | Ependymal cells, vascular structures and earlier wound-channel closure described | No verified quantitative motor outcome or intact-peptide brain exposure. |
Small animal comparison and descriptive histology. Printed concentration is unusually low and is retained as reported.
Source for the extracted data ↗ · Checked 2026-11-09
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Small animal comparison and descriptive histology. Printed concentration is unusually low and is retained as reported.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Original article, sections 2.13 and 3; DOI 10.60797/IRJ.2026.164.62
Review depth: Reported methods, results and evidence limitations
Source access and review scope
Original article, sections 2.13 and 3; DOI 10.60797/IRJ.2026.164.62
Recorded source-check date: 2026-11-09. This date does not imply a completed systematic review.
Source type: Original article, sections 2.13 and 3; DOI 10.60797/IRJ.2026.164.62
Citation and original source
Original source: V. P. Yamskova, M. S. Krasnov, P. A. Yelistratov, V. M. Chekova, E. V. Sidorskii, A. P. Ilina. PPC-M bovine brain complex: analytical and rat histology study Original article, sections 2.13 and 3; DOI 10.60797/IRJ.2026.164.62 2026.
Molekul research summary: https://molekul.io/research/ppc-m-cattle-brain-2026. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry