Efficacy of non-hormonal therapy in women with climacteric syndrome
M. I. Yarmolinskaya, N. A. Tatarova, V. N. Kasyan, A. S. Petrosyan · 2021 · Russian Bulletin of Obstetrician-Gynecologist. 21(2):91–101.
Study findings
The double-blind multicenter report found greater improvements in menopausal symptom and quality-of-life scores with Pineamin. Participants reported faster sleep onset and fewer nighttime awakenings; urinary melatonin sulfate was higher than with placebo.
- Population and setting
- 94 postmenopausal women: Pineamin 46, placebo 48
- Evidence type
- Randomized trial
- Preparation
- See the original report; formulation details require verification.
- Source language
- Russian
- Title source
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
Study limitations
- Sleep measures concern menopause-associated symptoms, not a general insomnia population or polysomnographic sleep architecture.
- The report evaluates several outcomes; statistical significance does not establish the size or durability of each benefit.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Source access and review scope
Publisher abstract and available HTML methods and results checked; no independent reanalysis.
Recorded source-check date: 2026-10-07. This date does not imply a completed systematic review.
Citation and original source
Original source: M. I. Yarmolinskaya, N. A. Tatarova, V. N. Kasyan, A. S. Petrosyan. Efficacy of non-hormonal therapy in women with climacteric syndrome Russian Bulletin of Obstetrician-Gynecologist. 21(2):91–101. 2021.
Molekul research summary: https://molekul.io/research/pineamin-sleep-2021. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry