Pineamin in combined therapy for diminished ovarian reserve
O. Yu. Tsygankova, E. N. Kravchenko, I. V. Savelyeva, I. V. Medyannikova, L. G. Makarkina, G. A. Gramovich · 2026 · Russian Bulletin of Obstetrician-Gynecologist. 26(1):56–62.
Study findings
The open randomized study reported IVF pregnancies in 14/36 participants receiving Pineamin with estrogen/progestogen versus 6/34 controls. Ultrasound and hormonal measures also favored the adjunctive group in the authors’ analysis.
- Population and setting
- 70 women: adjunctive Pineamin 36, comparison 34
- Evidence type
- Randomized trial
- Preparation
- See the original report; formulation details require verification.
- Source language
- Russian
- Title source
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
Study limitations
- Small open study with concomitant hormonal treatment. Pregnancy is not equivalent to live birth.
- Full statistical analysis, allocation procedures and longer follow-up require appraisal before drawing treatment conclusions.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Source access and review scope
Publisher abstract checked; full methods and supplementary data not appraised.
Recorded source-check date: 2026-10-07. This date does not imply a completed systematic review.
Citation and original source
Original source: O. Yu. Tsygankova, E. N. Kravchenko, I. V. Savelyeva, I. V. Medyannikova, L. G. Makarkina, G. A. Gramovich. Pineamin in combined therapy for diminished ovarian reserve Russian Bulletin of Obstetrician-Gynecologist. 26(1):56–62. 2026.
Molekul research summary: https://molekul.io/research/pineamin-ovarian-2026. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry