Recent tendencies in the prevention and treatment of menopausal syndrome
V. N. Prilepskaya, I. K. Bogatova, V. E. Radzinskiy · 2016 · Gynecology. 18(1):7–12.
Study findings
The multicenter double-blind trial reported improvement in modified Kupperman symptom scores versus placebo, principally neurovegetative symptoms. The two-course group retained a reported difference at day 180. Nineteen participants withdrew; 101 comprised the per-protocol population.
- Population and setting
- 120 postmenopausal women aged 45–60; placebo 30, one-course group 30, two-course group 60
- Evidence type
- Randomized trial
- Preparation
- Pineamin tissue-derived polypeptide mixture
- Source language
- Russian
- Title source
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
Study limitations
- The report recorded 22 adverse events; normal laboratory measures do not prove overall safety.
- Allocation concealment, missing-data handling and clinical importance of the score differences need detailed appraisal.
- Related 2015/2016 reports may describe the same cohort; do not count them as independent trials.
- Menopause symptom findings do not establish general insomnia treatment or longevity effects.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Journal report with Russian PDF
Related-report group: Pineamin menopause 120-woman program. Reports in this group are not assumed to be independent trials.
Source access and review scope
Publisher abstract and available Russian HTML methods inspected; PDF linked, not separately appraised.
Recorded source-check date: 2026-10-07. This date does not imply a completed systematic review.
Source type: Original clinical report
Citation and original source
Original source: V. N. Prilepskaya, I. K. Bogatova, V. E. Radzinskiy. Recent tendencies in the prevention and treatment of menopausal syndrome Gynecology. 18(1):7–12. 2016.
Molekul research summary: https://molekul.io/research/pineamin-menopause-2016. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry