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Pineamin increased pineal melatonin synthesis in elderly people

S. V. Trofimova, N. S. Linkova, A. A. Klimenko, T. V. Kvetnaia, V. Kh. Khavinson · 2017 · Adv Gerontol. 30(3):422–426. PMID 28849889.

Uncontrolled human reportEnglish abstractSource linked

This is Molekul’s research summary, not the original publication. Educational information only, not medical advice. Seek qualified healthcare help for medical conditions.

Study findings

The Russian abstract reports a 1.9-fold increase in nighttime urinary 6-sulfatoxymelatonin compared with the pretreatment value. This is a melatonin-metabolite finding, not a measured improvement in sleep architecture.

Population and setting: 55 older patients with reduced pineal melatonin function
Evidence type: Uncontrolled human report
Preparation: Pineamin polypeptide complex
Source language: Russian
Title source: Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.

Study limitations

Randomization and a concurrent placebo group are not established by the abstract.
The comparison with Epithalamin refers to earlier findings, not an established head-to-head trial.
No demonstrated REM-sleep, lifespan or healthy-person performance benefit follows from this biomarker.
Author affiliations include Geropharm; independent confirmation requires assessment.

Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.

Source access and review scope

PubMed English and Russian abstracts checked; full paper not reviewed.

Recorded source-check date: 2026-10-07. This date does not imply a completed systematic review.

Source type: Original human biomarker report

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Citation and original source

Original source: S. V. Trofimova, N. S. Linkova, A. A. Klimenko, T. V. Kvetnaia, V. Kh. Khavinson. Pineamin increased pineal melatonin synthesis in elderly people Adv Gerontol. 30(3):422–426. PMID 28849889. 2017.

Molekul research summary: https://molekul.io/research/pineamin-28849889. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.

Bibliography entry

Related compound profiles

Pineamin

A bovine pineal-gland polypeptide mixture investigated in menopausal symptoms and age-related melatonin physiology. It is distinct from Pinealon (EDR), synthetic Epitalon (AEDG), and the separately studied extract Epithalamin.

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