Short Peptides Protect Fibroblast-Derived Induced Neurons from Age-Related Changes.
Kraskovskaya N, Linkova N, Sakhenberg E, Krieger D, Polyakova V, Medvedev D, Krasichkov A, Khotin M, Ryzhak G · 2024 · International journal of molecular sciences; 2024 Oct
Study findings
EDR reduced oxidative DNA damage and promoted dendritic branching. The tested tripeptides did not improve mitochondrial or lysosomal activity or change p16 levels.
- Population and setting
- Induced cortical neurons derived from older human donors’ fibroblasts
- Evidence type
- In vitro
- Preparation
- See the original report; formulation details require verification.
- Source language
- eng
- Title source
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
Study limitations
- Human-derived cells are not a human treatment trial.
- Partial cellular effects do not establish reversal of brain aging, clinical benefit or safety.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Source access and review scope
Indexed publication and abstract checked; full methods and risk of bias have not been independently assessed.
Recorded source-check date: 2026-10-06. This date does not imply a completed systematic review.
Citation and original source
Original source: Kraskovskaya N, Linkova N, Sakhenberg E, Krieger D, Polyakova V, Medvedev D, Krasichkov A, Khotin M, Ryzhak G. Short Peptides Protect Fibroblast-Derived Induced Neurons from Age-Related Changes. International journal of molecular sciences; 2024 Oct 2024.
Molekul research summary: https://molekul.io/research/pinealon-39518916. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry