GHK and GQPR: combination compositions — WO2012164488A2
Arnaud Fournial, Philippe Mondon · 2012 · WO2012164488A2 · patent family 46246124
Published 2012-12-06.
Reported patent results
Reported findings
The mixture cream improved selected ultrasound and confocal imaging measures of superficial dermal structure.
Reported blinded randomized split-side cosmetic study in 28 women aged 51–72; peptide-mixture cream versus contralateral placebo for two months.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Inner-forearm SLEB depth and density | Placebo-adjusted changes: depth −11%, density approximately +15% | A thinner low-echogenic band and greater imaging density, not a clinical age reversal · 2 months · p<0.01 |
| Outer-forearm imaging | Depth/thickness −14.4%; density +15.1% | Changes reported for the light-exposed site · 2 months · p<0.01 |
| Papillary fibre-cluster circumference | +11.1% at one month and +13.9% at two months; placebo little or no change | Confocal surrogate endpoint · 1 and 2 months |
This is a branded peptide combination and cosmetic surrogate study. Results do not identify isolated GHK-Cu benefit, prove younger biological age or establish long-term clinical outcomes.
Source for the extracted data ↗ · Checked 2026-11-06
Patent claims and provenance
Formulation. This family describes peptide combinations involving GHK and GQPR, including lipid-modified variants.
A combination disclosure cannot identify the independent effect of GHK or be transferred to plain GHK-Cu.
- Publication
- WO2012164488A2 ↗ · 2012-12-06
- Earliest priority / filing
- 2011-06-01 / 2012-05-29
- Original applicant / assignee
- Sederma SA
- Indexed status
- Ceased · checked 2026-11-06
- Patent family
- 46246124 · family publications are related filings, not independent studies.
Original title, inventors and related publications
New cosmetic or dermopharmaceutical topical use of a mixture of a ghk tripeptide and gqpr tetrapeptide
Inventors: Arnaud Fournial; Philippe Mondon.
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- A combination disclosure cannot identify the independent effect of GHK or be transferred to plain GHK-Cu.
- This is a branded peptide combination and cosmetic surrogate study. Results do not identify isolated GHK-Cu benefit, prove younger biological age or establish long-term clinical outcomes.
- Patents record claimed inventions and supporting disclosures. Publication or grant does not establish clinical efficacy, safety or marketing approval. Members of one patent family and related journal reports can describe the same experiments.
- Status labels are Google Patents index snapshots for the displayed publication or application; the record gives its source-check date. Official registers and every national family member have not been independently checked. These labels do not establish freedom to operate.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Original patent text and indexed metadata
Review depth: Claims, selected reported findings and limitations reviewed; supporting experiments not comprehensively appraised.
Related-report group: patent-family-46246124. Reports in this group are not assumed to be independent trials.
Source access and review scope
Original patent publication accessed through Google Patents. Claims, selected reported findings and source limitations checked. The results section identifies the examples, tables and any numerical extraction gaps. No complete experimental audit, prosecution review or legal claim construction was performed.
Recorded source-check date: 2026-11-06. This date does not imply a completed systematic review.
Source type: Patent publication
Citation and original source
Original source: Arnaud Fournial, Philippe Mondon. GHK and GQPR: combination compositions — WO2012164488A2 WO2012164488A2 · patent family 46246124 2012.
Molekul research summary: https://molekul.io/research/patent-wo2012164488a2. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry