Thymodepressin: monosodium crystal polymorph — US8481588B2
Tim Fat Tam, Blaise N'Zemba, Regis Leung-Toung, Yingsheng Wang, Yanqing Zhao, Lily Yu · 2013 · US8481588B2 · patent family 39687890
Published 2013-07-09.
Reported patent results
Reported findings
The patent reports recovery of defined crystalline forms and conversion of a mixed preparation toward form F.
Solid-form experiments comparing and interconverting monosodium Thymodepressin polymorphs.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Selected conversion result | 38 mg recovered from a 50 mg portion, reported 78% yield; XRPD described as essentially form F | Analytical/manufacturing observation |
| Different polymorph example | Form X recovery reported at 60% yield, melting interval 182.3–186.1°C | A different crystal form, not a clinical comparator |
Crystal-form recovery and diffraction identity do not establish better autoimmune outcomes, absorption or safety. Polymorphs must not be conflated.
Source for the extracted data ↗ · Checked 2026-11-06
Patent claims and provenance
Formulation. This separate family concerns a particular monosodium crystalline form of the D-amino-acid dipeptide.
A distinct polymorph claim does not establish a different clinical mechanism or make every sodium formulation equivalent.
- Publication
- US8481588B2 ↗ · 2013-07-09
- Earliest priority / filing
- 2007-02-16 / 2012-06-07
- Original applicant / assignee
- Apotex Technologies Inc
- Indexed status
- Expired - Fee Related · checked 2026-11-06
- Patent family
- 39687890 · family publications are related filings, not independent studies.
Original title, inventors and related publications
Crystalline forms of the mono-sodium salt of D-isoglutamyl-D-tryptophan
Inventors: Tim Fat Tam; Blaise N'Zemba; Regis Leung-Toung; Yingsheng Wang; Yanqing Zhao; Lily Yu.
US8481588B2 · US8207217B2 · US8592607B2 · US8664262B2 · EP2121727A4 · CN103319393B · CA2579119C · RU2476440C2 · WO2008098355A1
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- A distinct polymorph claim does not establish a different clinical mechanism or make every sodium formulation equivalent.
- Crystal-form recovery and diffraction identity do not establish better autoimmune outcomes, absorption or safety. Polymorphs must not be conflated.
- Patents record claimed inventions and supporting disclosures. Publication or grant does not establish clinical efficacy, safety or marketing approval. Members of one patent family and related journal reports can describe the same experiments.
- Status labels are Google Patents index snapshots for the displayed publication or application; the record gives its source-check date. Official registers and every national family member have not been independently checked. These labels do not establish freedom to operate.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Original patent text and indexed metadata
Review depth: Claims, selected reported findings and limitations reviewed; supporting experiments not comprehensively appraised.
Related-report group: patent-family-39687890. Reports in this group are not assumed to be independent trials.
Source access and review scope
Original patent publication accessed through Google Patents. Claims, selected reported findings and source limitations checked. The results section identifies the examples, tables and any numerical extraction gaps. No complete experimental audit, prosecution review or legal claim construction was performed.
Recorded source-check date: 2026-11-06. This date does not imply a completed systematic review.
Source type: Patent publication
Citation and original source
Original source: Tim Fat Tam, Blaise N'Zemba, Regis Leung-Toung, Yingsheng Wang, Yanqing Zhao, Lily Yu. Thymodepressin: monosodium crystal polymorph — US8481588B2 US8481588B2 · patent family 39687890 2013.
Molekul research summary: https://molekul.io/research/patent-us8481588b2. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry