Thymodepressin
What is it?
Synthetic Glu–Trp-derived dipeptide in the suppressive branch of this research program. Stereochemistry and peptide-bond position matter.
Research context
Synthetic Glu–Trp-derived dipeptide in the suppressive branch of this research program. Stereochemistry and peptide-bond position matter.
- Working classification
- Peptide / preparation research
- Research collection
- Peptide bioregulation · editorial grouping
- Institutional provenance
- Not established for this compound record
- Last evidence review
- Full evidence review pending; source-check scope appears with each publication below.
What do we know?
- Human research
- —See preparation-specific records; human benefit not established here
- Study methods
- —Source-specific designs and limitations below
- Independent replication
- —Related reports are not automatically independent evidence
- Source access
- —Linked publications; access and review scope shown per record
- Safety evidence
- —Clinical safety, product equivalence and interactions not established by this collection
These are independent review fields, not a rating. Missing evidence in this starter does not mean no research exists.
Explore the expanded peptide research collection and unresolved source trails ↗
Linked sources
Explore the research map and unresolved leads ↗
Novel platform for the preparation of synthetic orally active peptidomimetics with hemoregulating activity. II. Hemosuppressor activity of 2,5-diketopiperazine-based cyclopeptides.
Preparation-specific research; no equivalence inferred
Deigin V, Ksenofontova O, Yatskin O, Goryacheva A, Ignatova A, Feofanov A, Ivanov V. · International immunopharmacology
The later platform paper studies suppressive cyclic derivatives. Opposing experimental effects do not establish a shared receptor or clinical interchangeability.
- Population / setting
- See original report; human, animal and laboratory components must be distinguished.
- What was checked
- Indexed metadata and abstract checked via Europe PMC. Original full methods not reviewed.
Limitations & review scope
- Full methods, preparation identity and risk of bias require appraisal.
- Related publications may share experiments; source count is not independent-study count.
Source checked 2026-10-02. This is a source-linked record, not a completed evidence review.
The effects of the EW--peptide optical and chemical isomers on the hemopoietic stem cells in intact and irradiated mice.
Preparation-specific research; no equivalence inferred
Deigin VI, Semenets TN, Zamulaeva IA, Maliutina YV, Selivanova EI, Saenko AS, Semina OV. · Advances in experimental medicine and biology
Follow-up record on optical and chemical isomers. No abstract was recovered; overlap with earlier experiments remains unresolved.
- Population / setting
- See original report; human, animal and laboratory components must be distinguished.
- What was checked
- Indexed metadata only checked via Europe PMC. Original full methods not reviewed.
Limitations & review scope
- Full methods, preparation identity and risk of bias require appraisal.
- Related publications may share experiments; source count is not independent-study count.
Source checked 2026-10-02. This is a source-linked record, not a completed evidence review.
Thymodepressin inhibits migration of CD34+ cells from bone marrow in normal and granulocyte CSF-stimulated hemopoiesis.
Preparation-specific research; no equivalence inferred
Semina OV, Semenets TN, Zamulaeva IA, Selivanova EI, Il'ina TP, Malyutina YV, Semin DY, Deigin VI, Saenko AS. · Bulletin of experimental biology and medicine
Mouse CD34-positive cell distribution and adhesion-marker changes suggest altered trafficking. They do not identify a direct molecular receptor or demonstrate human stem-cell expansion.
- Population / setting
- See original report; human, animal and laboratory components must be distinguished.
- What was checked
- Indexed metadata and abstract checked via Europe PMC. Original full methods not reviewed.
Limitations & review scope
- Full methods, preparation identity and risk of bias require appraisal.
- Related publications may share experiments; source count is not independent-study count.
Source checked 2026-10-02. This is a source-linked record, not a completed evidence review.
The effects of the EW dipeptide optical and chemical isomers on the CFU-S population in intact and irradiated mice.
Preparation-specific research; no equivalence inferred
Deigin VI, Semenets TN, Zamulaeva IA, Maliutina YV, Selivanova EI, Saenko AS, Semina OV. · International immunopharmacology
Optical configuration, peptide linkage and administration before or after irradiation affected colony-forming responses. Normal marrow and injury recovery are different endpoints.
- Population / setting
- See original report; human, animal and laboratory components must be distinguished.
- What was checked
- Indexed metadata and abstract checked via Europe PMC. Original full methods not reviewed.
Limitations & review scope
- Full methods, preparation identity and risk of bias require appraisal.
- Related publications may share experiments; source count is not independent-study count.
Source checked 2026-10-02. This is a source-linked record, not a completed evidence review.
Effects of structural and "mixed" isomers of Glu-Trp dipeptide on normal hemopoietic stem cells.
Preparation-specific research; no equivalence inferred
Semina OV, Semenets TN, Zamulaeva IA, Selivanova EI, Malyutina YV, Saenko AS, Deigin VI. · Bulletin of experimental biology and medicine
Glu–Trp isomers produced different colony-assay effects depending on stereochemistry and bond position. Results cannot be reduced to a universal L-stimulates/D-suppresses rule.
- Population / setting
- See original report; human, animal and laboratory components must be distinguished.
- What was checked
- Indexed metadata and abstract checked via Europe PMC. Original full methods not reviewed.
Limitations & review scope
- Full methods, preparation identity and risk of bias require appraisal.
- Related publications may share experiments; source count is not independent-study count.
Source checked 2026-10-02. This is a source-linked record, not a completed evidence review.
[Thymodepressin protects murine bone marrow CFU-S from the hyperthermic damage].
Preparation-specific research; no equivalence inferred
Semenets TN, Semina OV, Deĭgin VI, Maliutina IaV, Saenko AS. · Radiatsionnaia biologiia, radioecologiia
Experiments found differing heat responses in normal marrow precursors and tumor model cells. Heating cells to 43°C does not demonstrate whole-body heat tolerance or occupational protection.
- Population / setting
- See original report; human, animal and laboratory components must be distinguished.
- What was checked
- Indexed metadata and abstract checked via Europe PMC. Original full methods not reviewed.
Limitations & review scope
- Full methods, preparation identity and risk of bias require appraisal.
- Related publications may share experiments; source count is not independent-study count.
Source checked 2026-10-02. This is a source-linked record, not a completed evidence review.
Synthetic peptide thymodepressin promoted take of transplanted hemopoietic precursor cells in the bone marrow of irradiated mice.
Preparation-specific research; no equivalence inferred
Semina OV, Semenets TN, Poverennyi AM, Deigin VI. · Bulletin of experimental biology and medicine
A mouse transplantation experiment measured donor-cell colony formation following pretreatment and irradiation. The proposed marrow-microenvironment mechanism remains a hypothesis.
- Population / setting
- See original report; human, animal and laboratory components must be distinguished.
- What was checked
- Indexed metadata and abstract checked via Europe PMC. Original full methods not reviewed.
Limitations & review scope
- Full methods, preparation identity and risk of bias require appraisal.
- Related publications may share experiments; source count is not independent-study count.
Source checked 2026-10-02. This is a source-linked record, not a completed evidence review.
[The synthetic peptide D-(iEW) (thymodepressin) protects bone marrow CFU-S from ionizing radiation exposure].
Preparation-specific research; no equivalence inferred
Semina OV, Deĭgin VI, Semenets TN, Beziaev GP, Poverennyĭ AM. · Radiatsionnaia biologiia, radioecologiia
Pre-irradiation treatment reduced the cycling fraction of marrow colony-forming cells and was associated with later colony recovery. Timing and model are essential to interpretation.
- Population / setting
- See original report; human, animal and laboratory components must be distinguished.
- What was checked
- Indexed metadata and abstract checked via Europe PMC. Original full methods not reviewed.
Limitations & review scope
- Full methods, preparation identity and risk of bias require appraisal.
- Related publications may share experiments; source count is not independent-study count.
Source checked 2026-10-02. This is a source-linked record, not a completed evidence review.
Advancement from Small Peptide Pharmaceuticals to Orally Active Piperazine-2,5-dion-Based Cyclopeptides
Defined synthetic peptide / analogue
Vladislav Deigin, Natalia Linkova, Olga Volpina · International Journal of Molecular Sciences 24(17):13534
Development-group review connecting small peptides with cyclic peptidomimetics, including AWE18. AWE18 and CP-88 are separate candidates. Review descriptions of oral activity are not independent clinical trials.
- Population / setting
- Source-specific experimental population
- What was checked
- Review full text retrieved via Europe PMC. Primary compound-specific studies require separate appraisal.
Limitations & review scope
- Independent replication and full risk-of-bias appraisal remain unresolved.
- No personalized treatment or safety conclusion follows from this record.
Source checked 2026-10-02. This is a source-linked record, not a completed evidence review.