Cortagen: AEDP molecular and neuronal-use claims — US7189701B1
Vladimir K. Khavinson, Vyacheslav G. Morozov, Vladimir V. Malinin, Evgeny I. Grigoriev · 2007 · US7189701B1 · patent family 20225904
Published 2007-03-13.
Reported patent results
Reported findings
The trauma comparison reports better test scores during Cortagen-containing care. The dementia percentage claim is not consistent with a straightforward 12-person responder count.
Cortagen patent: 35 post-traumatic patients in three groups (15 Cortagen, 10 conventional care, 10 Cerebrolysin adjunct); separate 12-patient vascular-dementia example.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Trauma corrective test: characters | 2,519.6 ± 105.3 Cortagen, 2,193.3 ± 120.6 Cerebrolysin, 1,977.4 ± 186.4 conventional care | Three patent-described treatment groups · Cortagen versus conventional: p<0.05 |
| Trauma corrective test: mistakes | 6.3 ± 1.1, 9.4 ± 1.7 and 10.5 ± 1.9, respectively | Same group order; not a blinded modern cognitive trial |
| Dementia example | Narrative claims 74.8% symptom reversal among 12 patients | This percentage cannot be converted into an exact number of responders; no contemporary control specified |
Unverified allocation/masking, small cohorts and reporting inconsistencies limit inference. Shared EEG values with the Pinealon patent do not establish independent replication; no proven brain repair follows.
Source for the extracted data ↗ · Checked 2026-11-06
Patent claims and provenance
Molecule. The claims identify Ala-Glu-Asp-Pro and related neuronal-function compositions and uses.
The defined tetrapeptide differs from the Cortexin extract; proposed neuronal effects are not established clinical outcomes.
- Publication
- US7189701B1 ↗ · 2007-03-13
- Earliest priority / filing
- 1999-10-20 / 2000-05-25
- Original applicant / assignee
- Nostiji "Klinika Instituta Bioregulyatsii Gerontologii" OOO
- Indexed status
- Expired - Fee Related · checked 2026-11-06
- Patent family
- 20225904 · family publications are related filings, not independent studies.
Original title, inventors and related publications
Tetrapeptide stimulating functional activity of neurons pharmacological agent based thereon and method of use thereof
Inventors: Vladimir K. Khavinson; Vyacheslav G. Morozov; Vladimir V. Malinin; Evgeny I. Grigoriev.
US7189701B1 · EP1224212B1 · JP4668497B2 · ATE244727T1 · AU784578B2 · CA2388357A1 · DE60003837T2 · IL149243A0 · RU2155063C1 · WO2001029067A1
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- The defined tetrapeptide differs from the Cortexin extract; proposed neuronal effects are not established clinical outcomes.
- Unverified allocation/masking, small cohorts and reporting inconsistencies limit inference. Shared EEG values with the Pinealon patent do not establish independent replication; no proven brain repair follows.
- Patents record claimed inventions and supporting disclosures. Publication or grant does not establish clinical efficacy, safety or marketing approval. Members of one patent family and related journal reports can describe the same experiments.
- Status labels are Google Patents index snapshots for the displayed publication or application; the record gives its source-check date. Official registers and every national family member have not been independently checked. These labels do not establish freedom to operate.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Original patent text and indexed metadata
Review depth: Claims, selected reported findings and limitations reviewed; supporting experiments not comprehensively appraised.
Related-report group: patent-family-20225904. Reports in this group are not assumed to be independent trials.
Source access and review scope
Original patent publication accessed through Google Patents. Claims, selected reported findings and source limitations checked. The results section identifies the examples, tables and any numerical extraction gaps. No complete experimental audit, prosecution review or legal claim construction was performed.
Recorded source-check date: 2026-11-06. This date does not imply a completed systematic review.
Source type: Patent publication
Citation and original source
Original source: Vladimir K. Khavinson, Vyacheslav G. Morozov, Vladimir V. Malinin, Evgeny I. Grigoriev. Cortagen: AEDP molecular and neuronal-use claims — US7189701B1 US7189701B1 · patent family 20225904 2007.
Molekul research summary: https://molekul.io/research/patent-us7189701b1. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry