Pal-GHK-R4: granted US claim is narrower than the abstract — US11912787B2
Hoon Cha, Young Il KWON, Sang Cheol Han, Jin Wook Kim, Mi Young Lee, Ga Hee HUR · 2024 · US11912787B2 · patent family 71842232
Published 2024-02-27.
Reported patent results
Reported findings
The modified peptides affected MMP activity and collagen at lower tested concentrations than GHK-acetate.
UVB-stressed Hs68 fibroblast experiments comparing GHK-acetate, GHK-R4 and Pal-GHK-R4.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| MMP-2 inhibition | GHK-R4 active at about one-tenth, Pal-GHK-R4 at about one-hundredth, the stated GHK-acetate concentration | Concentration comparison in a laboratory assay, not a clinical potency ratio |
| Collagen synthesis | GHK-R4 active at about one-fifth and Pal-GHK-R4 at about one-hundredth the GHK-acetate concentration | Concentration-dependent increases after UVB stress; no human wrinkle measurements |
| MMP-9 expression | Reduced with the peptides, with modified analogues active at lower concentrations | Directional laboratory outcome; no numerical between-group estimate supplied |
Assay concentration ratios do not demonstrate equivalent clinical effects or a hundredfold human benefit. The granted US claim specifically requires Pal-GHK-R4.
Source for the extracted data ↗ · Checked 2026-11-06
Patent claims and provenance
Modified analogue. US claim 1 requires both an N-terminal palmitoyl group and four C-terminal arginines attached to GHK.
The broader family description also discusses GHK-R4. The granted US claim must not be read as a claim to ordinary GHK, GHK-Cu or every unpalmitoylated R4 construct.
- Publication
- US11912787B2 ↗ · 2024-02-27
- Earliest priority / filing
- 2019-01-28 / 2020-01-22
- Original applicant / assignee
- Dermafirm Inc
- Indexed status
- Active · checked 2026-11-06
- Patent family
- 71842232 · family publications are related filings, not independent studies.
Original title, inventors and related publications
Peptide for skin aging prevention and wrinkle reduction, and composition comprising same
Inventors: Hoon Cha; Young Il KWON; Sang Cheol Han; Jin Wook Kim; Mi Young Lee; Ga Hee HUR.
US11912787B2 · KR102203356B1 · CN113271957B · WO2020159143A1
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- The broader family description also discusses GHK-R4. The granted US claim must not be read as a claim to ordinary GHK, GHK-Cu or every unpalmitoylated R4 construct.
- Assay concentration ratios do not demonstrate equivalent clinical effects or a hundredfold human benefit. The granted US claim specifically requires Pal-GHK-R4.
- Patents record claimed inventions and supporting disclosures. Publication or grant does not establish clinical efficacy, safety or marketing approval. Members of one patent family and related journal reports can describe the same experiments.
- Status labels are Google Patents index snapshots for the displayed publication or application; the record gives its source-check date. Official registers and every national family member have not been independently checked. These labels do not establish freedom to operate.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Original patent text and indexed metadata
Review depth: Claims, selected reported findings and limitations reviewed; supporting experiments not comprehensively appraised.
Related-report group: patent-family-71842232. Reports in this group are not assumed to be independent trials.
Source access and review scope
Original patent publication accessed through Google Patents. Claims, selected reported findings and source limitations checked. The results section identifies the examples, tables and any numerical extraction gaps. No complete experimental audit, prosecution review or legal claim construction was performed.
Recorded source-check date: 2026-11-06. This date does not imply a completed systematic review.
Source type: Patent publication
Citation and original source
Original source: Hoon Cha, Young Il KWON, Sang Cheol Han, Jin Wook Kim, Mi Young Lee, Ga Hee HUR. Pal-GHK-R4: granted US claim is narrower than the abstract — US11912787B2 US11912787B2 · patent family 71842232 2024.
Molekul research summary: https://molekul.io/research/patent-us11912787b2. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry