GHK: 2011 thermal-pain response patent — RU2421235C1
Максим Евгеньевич Долгинцев, Игорь Иванович Бобынцев, Михаил Юрьевич Смахтин, Алексей Анатольевич Крюков, Ольга Игоревна Иванова, Андрей Евгеньевич Белых · 2011 · RU2421235C1 · patent family 44737905
Published 2011-06-20.
Reported patent results
Reported findings
Copper-free GHK increased thermal-pain response latency in male mice compared with saline. This is preclinical patent evidence.
Male BALB/c mice; 10 per group; saline control and two GHK exposure groups. Randomization and blinding are not described.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Pain-response latency, lower GHK exposure | 25.6 ± 1.9 seconds versus 18.0 ± 2.4 seconds with saline | Copper-free GHK 0.5 µg/kg; 10 mice/group; table reports M±m · Acute thermal-pain test after pretreatment · p<0.05 versus saline |
| Pain-response latency, higher GHK exposure | 23.6 ± 1.3 seconds versus 18.0 ± 2.4 seconds with saline | Copper-free GHK 5 µg/kg; 10 mice/group; table reports M±m · Same acute comparison · p<0.05 versus saline |
| Exposure-response interpretation | Both groups differed from saline; no between-dose significance test or persistent analgesic effect was established | The numerically lower latency at the higher exposure does not establish a dose-response relationship |
| Treatment-to-test interval | 12 minutes in the described experiment |
Animal behavioral endpoint, not human pain relief. The table supplies M±m without expanding the dispersion notation; no confidence intervals, formal safety assessment or independent replication are established. Copper binding was not part of the tested preparation.
Source for the extracted data ↗ · Checked 2026-11-07
Patent claims and provenance
Use. The single claim concerns copper-free Gly-His-Lys for thermal-pain analgesia, supported by a mouse comparison.
Unbound GHK is not GHK-Cu. A mouse pain-response result does not establish human analgesia or a new clinical indication.
- Publication
- RU2421235C1 ↗ · 2011-06-20
- Earliest priority / filing
- 2010-04-12 / 2010-04-12
- Original applicant / assignee
- Kursk State Medical University
- Indexed status
- IP Right Cessation — indexed historical event; official status unverified · checked 2026-11-07
- Patent family
- 44737905 · family publications are related filings, not independent studies.
Original title, inventors and related publications
APPLICATION OF PEPTIDE Gly-His-Lys FOR ANALGESIC EFFECT IN PAIN CAUSED BY THERMAL IRRITATION
Inventors: Максим Евгеньевич Долгинцев; Игорь Иванович Бобынцев; Михаил Юрьевич Смахтин; Алексей Анатольевич Крюков; Ольга Игоревна Иванова; Андрей Евгеньевич Белых.
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Unbound GHK is not GHK-Cu. A mouse pain-response result does not establish human analgesia or a new clinical indication.
- Animal behavioral endpoint, not human pain relief. The table supplies M±m without expanding the dispersion notation; no confidence intervals, formal safety assessment or independent replication are established. Copper binding was not part of the tested preparation.
- Patents record claimed inventions and supporting disclosures. Publication or grant does not establish clinical efficacy, safety or marketing approval. Members of one patent family and related journal reports can describe the same experiments.
- Status labels are Google Patents index snapshots for the displayed publication or application; the record gives its source-check date. Official registers and every national family member have not been independently checked. These labels do not establish freedom to operate.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Original patent text and indexed metadata
Review depth: Claims, selected reported findings and limitations reviewed; supporting experiments not comprehensively appraised.
Related-report group: patent-family-44737905. Reports in this group are not assumed to be independent trials.
Source access and review scope
Original patent publication accessed through Google Patents. Claims, selected reported findings and source limitations checked. The results section identifies the examples, tables and any numerical extraction gaps. No complete experimental audit, prosecution review or legal claim construction was performed.
Recorded source-check date: 2026-11-07. This date does not imply a completed systematic review.
Source type: Patent publication
Citation and original source
Original source: Максим Евгеньевич Долгинцев, Игорь Иванович Бобынцев, Михаил Юрьевич Смахтин, Алексей Анатольевич Крюков, Ольга Игоревна Иванова, Андрей Евгеньевич Белых. GHK: 2011 thermal-pain response patent — RU2421235C1 RU2421235C1 · patent family 44737905 2011.
Molekul research summary: https://molekul.io/research/patent-ru2421235c1. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry