APHC family: additional analgesic peptide variants — RU2404245C1
Сергей Александрович Козлов (RU), Сергей Александрович Козлов, Ярослав Алексеевич Андреев (RU), Ярослав Алексеевич Андреев, Аркадий Николаевич Мурашев (RU), Аркадий Николаевич Мурашев, Евгений Васильевич Гришин (RU), Евгений Васильевич Гришин · 2010 · RU2404245C1 · patent family 44058440
Published 2010-11-20.
Reported patent results
Reported findings
The variants differed in temperature effects, illustrating that related peptides are not interchangeable.
Mouse experiments on APHC-family variants, with APHC1 as a comparator; analgesic behavior and body temperature were assessed.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Temperature decrease | Approximately 0.5–1°C reported for APHC1 around 40 minutes and APHC3 around 80 minutes | An animal physiological effect, not a clinical therapeutic endpoint |
| Neutral variant | No significant body-temperature decrease detected with APHC2 | Variant-specific neutral observation retained |
| Pain-behavior assays | Analgesic-like responses assessed against controls; figure-level effect sizes not transcribed | No human pain comparison |
Family resemblance does not establish identical effects or safety. Temperature effects and small-animal pain assays cannot demonstrate human efficacy.
Source for the extracted data ↗ · Checked 2026-11-06
Patent claims and provenance
Molecule. The claim defines related sea-anemone peptide variants with specified amino-acid substitutions.
Family-level sequence claims must not be transferred to unrelated marine peptides; human clinical efficacy has not been established here.
- Publication
- RU2404245C1 ↗ · 2010-11-20
- Earliest priority / filing
- 2009-07-09 / 2009-07-09
- Original applicant / assignee
- Учреждение Российской академии наук Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова РАН
- Indexed status
- Not shown; official status unverified · checked 2026-11-06
- Patent family
- 44058440 · family publications are related filings, not independent studies.
Original title, inventors and related publications
Actinia polypeptide, possessing analgesic action
Inventors: Сергей Александрович Козлов (RU); Сергей Александрович Козлов; Ярослав Алексеевич Андреев (RU); Ярослав Алексеевич Андреев; Аркадий Николаевич Мурашев (RU); Аркадий Николаевич Мурашев; Евгений Васильевич Гришин (RU); Евгений Васильевич Гришин.
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Family-level sequence claims must not be transferred to unrelated marine peptides; human clinical efficacy has not been established here.
- Family resemblance does not establish identical effects or safety. Temperature effects and small-animal pain assays cannot demonstrate human efficacy.
- Patents record claimed inventions and supporting disclosures. Publication or grant does not establish clinical efficacy, safety or marketing approval. Members of one patent family and related journal reports can describe the same experiments.
- Status labels are Google Patents index snapshots for the displayed publication or application; the record gives its source-check date. Official registers and every national family member have not been independently checked. These labels do not establish freedom to operate.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Original patent text and indexed metadata
Review depth: Claims, selected reported findings and limitations reviewed; supporting experiments not comprehensively appraised.
Related-report group: patent-family-44058440. Reports in this group are not assumed to be independent trials.
Source access and review scope
Original patent publication accessed through Google Patents. Claims, selected reported findings and source limitations checked. The results section identifies the examples, tables and any numerical extraction gaps. No complete experimental audit, prosecution review or legal claim construction was performed.
Recorded source-check date: 2026-11-06. This date does not imply a completed systematic review.
Source type: Patent publication
Citation and original source
Original source: Сергей Александрович Козлов (RU), Сергей Александрович Козлов, Ярослав Алексеевич Андреев (RU), Ярослав Алексеевич Андреев, Аркадий Николаевич Мурашев (RU), Аркадий Николаевич Мурашев, Евгений Васильевич Гришин (RU), Евгений Васильевич Гришин. APHC family: additional analgesic peptide variants — RU2404245C1 RU2404245C1 · patent family 44058440 2010.
Molekul research summary: https://molekul.io/research/patent-ru2404245c1. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry