Bromantane use as an immunostimulant — RU1826906C
I. S. Morozov, N. G. Artsimovich, T. A. Fadeeva, N. V. Klimova, T. S. Galushina, M. A. Matvienko, B. M. Pyatin, N. M. Zaitseva, S. B. Seredenin, B. I. Lyubimov, N. I. Avdyunina, N. A. Kislyak, O. A. Mikhailova, I. A. Ivanova, O. I. Aksenova, S. A. Sergeeva, V. G. Barchukov, Yu. N. Belyi, V. I. Ratnikov, L. M. Krasnykh · 1993 · RU1826906C · patent family 21580448
Published 1993-07-07.
Reported patent results
Reported findings
The inventors reported an increase in large circulating immune complexes three hours after Bromantane in healthy volunteers. The reported significance concerns a change from baseline.
The patent calls the volunteer experiment double-blind. It gives an overall figure of 37 healthy volunteers but identifies 12 given a single 200 mg oral Bromantane dose and 11 given placebo for this comparison. Blood was sampled at baseline and three hours.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Large circulating immune complexes | Increased at 3 hours | Bromantane arm versus its baseline. Placebo arm showed no significant change from baseline. |
| Small circulating immune complexes | Nonsignificant decrease | Bromantane arm versus its baseline. |
| B-cell functional activity in immunodeficient mice | 75–85% vs 30–35% | Patent’s summary of reported recovery with Bromantane and Kemantane, respectively. A common denominator for those percentages is unclear. |
The specified volunteer arms account for 23 of the 37 people mentioned. The filing does not give a direct between-arm statistical test. The 1996 mouse papers may share experiments with the filing.
Source for these results ↗ · Reviewed 2026-11-10
Patent claims and provenance
Use. The filing claims Bromantane for immunostimulant use and describes animal immune assays and a healthy-volunteer blood-marker experiment.
The volunteer experiment measured a circulating marker over three hours. The filing does not demonstrate infection prevention or efficacy in an immune disorder.
- Publication
- RU1826906C ↗ · 1993-07-07
- Earliest priority / filing
- 1991-06-21 / 1991-06-21
- Original applicant / assignee
- Research Institute of Pharmacology
- Indexed status
- Not shown; official status unverified · checked 2026-11-10
- Patent family
- 21580448 · family publications are related filings, not independent studies.
Original title, inventors and related publications
Иммуностимулирующее средство «Бромантан»
Inventors: I. S. Morozov; N. G. Artsimovich; T. A. Fadeeva; N. V. Klimova; T. S. Galushina; M. A. Matvienko; B. M. Pyatin; N. M. Zaitseva; S. B. Seredenin; B. I. Lyubimov; N. I. Avdyunina; N. A. Kislyak; O. A. Mikhailova; I. A. Ivanova; O. I. Aksenova; S. A. Sergeeva; V. G. Barchukov; Yu. N. Belyi; V. I. Ratnikov; L. M. Krasnykh.
For research and education. Consult a qualified clinician for medical advice.
Study limitations and source details
Study limitations
- The volunteer experiment measured a circulating marker over three hours. The filing does not demonstrate infection prevention or efficacy in an immune disorder.
- The specified volunteer arms account for 23 of the 37 people mentioned. The filing does not give a direct between-arm statistical test. The 1996 mouse papers may share experiments with the filing.
- Patents record claimed inventions and supporting disclosures. Publication or grant does not establish clinical efficacy, safety or marketing approval. Members of one patent family and related journal reports can describe the same experiments.
- Status labels are Google Patents index snapshots for the displayed publication or application; each record lists the review date. Official registers and every national family member have not been independently checked. These labels do not establish freedom to operate.
Available format: Original patent text and indexed metadata
Material reviewed: Claims, selected reported findings and limitations reviewed; supporting experiments not comprehensively appraised.
Related publications may cover the same research program or participants.
Source access
Original patent publication accessed through Google Patents. Claims, selected reported findings and source limitations checked. The results section identifies the examples, tables and any numerical extraction gaps. No complete experimental audit, prosecution review or legal claim construction was performed.
Source reviewed 2026-11-10.
Source type: Patent publication
Citation and original source
Original source: I. S. Morozov, N. G. Artsimovich, T. A. Fadeeva, N. V. Klimova, T. S. Galushina, M. A. Matvienko, B. M. Pyatin, N. M. Zaitseva, S. B. Seredenin, B. I. Lyubimov, N. I. Avdyunina, N. A. Kislyak, O. A. Mikhailova, I. A. Ivanova, O. I. Aksenova, S. A. Sergeeva, V. G. Barchukov, Yu. N. Belyi, V. I. Ratnikov, L. M. Krasnykh. Bromantane use as an immunostimulant — RU1826906C RU1826906C · patent family 21580448 1993.
Molekul research summary: https://molekul.io/research/patent-ru1826906c. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry