Peptidergic regulation of age-related alterations in the cardiovascular system
Ryzhak GA, Popovich IG, Kozina LS, Arutionov VA, Arutjunyan AV · 2026 · Advances in gerontology = Uspekhi gerontologii 39(4)
Indexed 2026-10-27.
Reported findings and study design
The review brings together vascular polypeptide, KED and AEDR research. It describes changes in endothelial endothelin-1 expression, vascular hemodynamics and experimental myocardial injury. These preparation-specific observations are preclinical; the review supplies no new human cardiovascular efficacy trial.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Preparations reviewed | Vascular polypeptide preparation, KED and AEDR | |
| Endothelial findings | KED restored elevated ET-1 expression toward normal in reported cultures | Cultures derived from patients are not a clinical treatment trial |
| Cardiac findings | AEDR experimental cardioprotection summarized | Animal experiments; no new human trial |
Review of earlier experiments, not independent replication. Vascular extracts, KED and AEDR are different preparations; effects cannot be transferred between them. Exact publication day is not supplied by the index; newly indexed 28 October 2026.
Source for the extracted data ↗ · Checked 2026-10-31
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Review of earlier experiments, not independent replication. Vascular extracts, KED and AEDR are different preparations; effects cannot be transferred between them. Exact publication day is not supplied by the index; newly indexed 28 October 2026.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Indexed abstract checked
Source access and review scope
Primary publication metadata and indexed abstract checked through Europe PMC on 31 October 2026. No unavailable effect sizes inferred.
Recorded source-check date: 2026-10-31. This date does not imply a completed systematic review.
Source type: Journal publication
Citation and original source
Original source: Ryzhak GA, Popovich IG, Kozina LS, Arutionov VA, Arutjunyan AV. Peptidergic regulation of age-related alterations in the cardiovascular system Advances in gerontology = Uspekhi gerontologii 39(4) 2026.
Molekul research summary: https://molekul.io/research/oct31-42935327. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entryRelated compound profiles
Cardiogen
AEDR tetrapeptide studied in rat heart explants and tumor models. Heart-culture proliferation and p53 changed; no human cardiac recovery has been established.
Vesugen
A peptide research entry in the Khavinson evidence map. Direct studies, related extract findings, institute reports and unresolved claims are distinguished below.
KED
A tripeptide research entry connected to experimental neurodegeneration work. No human benefit is inferred from mouse-model findings.
Vasolin / Slavinorm
Vessel-derived polypeptide research collection including Slavinorm. Separate arterial, venous and rehabilitation reports now link here. These complex preparations are not interchangeable with purified KED or every historical Vasolin formulation.