APETx-Like Peptides from the Sea Anemone Heteractis crispa , Diverse in Their Effect on ASIC1a and ASIC3 Ion Channels
Kalina Rimma S., Koshelev Sergey G., Zelepuga Elena A., Kim Natalia Y., Kozlov Sergey A., Kozlovskaya Emma P., Monastyrnaya Margarita M., Gladkikh Irina N. · 2020 · Toxins. 2020;12(4):266.
Study findings
Hcr 1b-4 inhibited ASIC1a but potentiated ASIC3; Hcr 1b-3 inhibited both tested channels.
- Population and setting
- Recombinant peptides, expressed rat ASIC channels and molecular modeling
- Evidence type
- In vitro
- Source language
- English
- Title source
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
Study limitations
- Channel pharmacology and modeling do not establish stroke protection.
- Opposite effects on ASIC subtypes must not be summarized as universal ASIC blockade.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Source access and review scope
Repository primary abstract checked; full-text resource retrieved. Detailed tables not independently appraised.
Recorded source-check date: 2026-10-11. This date does not imply a completed systematic review.
Citation and original source
Original source: Kalina Rimma S., Koshelev Sergey G., Zelepuga Elena A., Kim Natalia Y., Kozlov Sergey A., Kozlovskaya Emma P., Monastyrnaya Margarita M., Gladkikh Irina N.. APETx-Like Peptides from the Sea Anemone Heteractis crispa , Diverse in Their Effect on ASIC1a and ASIC3 Ion Channels Toxins. 2020;12(4):266. 2020.
Molekul research summary: https://molekul.io/research/oct11-32326130. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry