The effect of GHK-PGP peptide and its analogues on the rat’s behavior in the forced swimming test
M. E. Alferova, I. I. Bobyntsev, A. O. Vorvul, A. N. Tenkova, L. A. Andreeva, N. F. Myasoedov · 2026 · Molecular Medicine. 2026;24(4):32–35.
Related evidence maps: Sports performance ↗
Reported findings and study design
200 male Wistar rats; forced-swim behavioral test.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| GHK-GP forced-swim behavior | No effect at any tested exposure | |
| GHK-PGP / GHK-VEP forced-swim behavior | Selected-exposure changes; authors describe antidepressant-like activity | Animal behavioral proxy; not human depression outcomes |
Animal findings do not establish human efficacy, a human dose, or long-term safety. Forced-swim behavior is not a clinical diagnosis or evidence of antidepressant efficacy in people. A higher activity score can have several explanations; complete locomotor controls and risk of bias require review.
Source for the extracted data ↗ · Checked 2026-11-03
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Animal findings do not establish human efficacy, a human dose, or long-term safety.
- Forced-swim behavior is not a clinical diagnosis or evidence of antidepressant efficacy in people.
- A higher activity score can have several explanations; complete locomotor controls and risk of bias require review.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Source access and review scope
Primary publisher English abstract checked; Russian full text not appraised.
Recorded source-check date: 2026-11-03. This date does not imply a completed systematic review.
Citation and original source
Original source: M. E. Alferova, I. I. Bobyntsev, A. O. Vorvul, A. N. Tenkova, L. A. Andreeva, N. F. Myasoedov. The effect of GHK-PGP peptide and its analogues on the rat’s behavior in the forced swimming test Molecular Medicine. 2026;24(4):32–35. 2026.
Molekul research summary: https://molekul.io/research/ghk-proline-swim-2026. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry