Speech Therapy Combined With Cerebrolysin in Enhancing Nonfluent Aphasia Recovery After Acute Ischemic Stroke: ESCAS Randomized Pilot Study.
Homberg V, Jianu DC, Stan A, Strilciuc Ș, Chelaru VF, Karliński M, Brainin M, Heiss WD, Muresanu DF, Enderby PM · 2025 · Stroke; 2025 Apr
Study findings
With speech therapy in both groups, the Cerebrolysin group showed greater improvement in language scores at 90 days than placebo, alongside neurological improvement.
- Population and setting
- ESCAS: 132 enrolled; 123 in intention-to-treat analysis
- Evidence type
- Randomized trial
- Preparation
- See the original report; formulation details require verification.
- Source language
- eng
- Title source
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
Study limitations
- Pilot trial in a selected nonfluent-aphasia population; generalizability is limited.
- Difference between enrolled and analyzed populations requires full-methods review.
- Full methods and risk of bias have not been independently assessed.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Source access and review scope
Indexed record and available abstract checked; full text not reviewed.
Recorded source-check date: 2026-10-07. This date does not imply a completed systematic review.
Citation and original source
Original source: Homberg V, Jianu DC, Stan A, Strilciuc Ș, Chelaru VF, Karliński M, Brainin M, Heiss WD, Muresanu DF, Enderby PM. Speech Therapy Combined With Cerebrolysin in Enhancing Nonfluent Aphasia Recovery After Acute Ischemic Stroke: ESCAS Randomized Pilot Study. Stroke; 2025 Apr 2025.
Molekul research summary: https://molekul.io/research/cbl-update-39957612. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry