[Neurochemical study of effects of the new anxiolytic drugs afobazol and ladasten on the synthesis and metabolism of monoamines and their metabolites in the brain structures of Wistar rat on the model of monoamine synthesis blockade induced by aromatic amino acid decarboxylase inhibitor NSD-1015].
Davydova AI, Klodt PM, Kudrin VS, Kuznetsova EA, Narkevich VB · 2010 · Eksperimental'naia i klinicheskaia farmakologiia; 2010 Mar
Study findings
Under experimental blockade of monoamine synthesis, Ladasten increased L-DOPA in several rat brain regions and altered dopamine-metabolism indices. Effects differed from the afobazole comparator.
- Population and setting
- Animal or animal-tissue experiments
- Evidence type
- Animal / experimental
- Preparation
- See the original report; formulation details require verification.
- Source language
- rus
- Title source
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
Study limitations
- Original full text and detailed methods have not been reviewed.
- Experimental findings do not establish human efficacy, dosing or long-term safety.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Source access and review scope
Indexed citation and English abstract checked.
Recorded source-check date: 2026-10-07. This date does not imply a completed systematic review.
Citation and original source
Original source: Davydova AI, Klodt PM, Kudrin VS, Kuznetsova EA, Narkevich VB. [Neurochemical study of effects of the new anxiolytic drugs afobazol and ladasten on the synthesis and metabolism of monoamines and their metabolites in the brain structures of Wistar rat on the model of monoamine synthesis blockade induced by aromatic amino acid decarboxylase inhibitor NSD-1015]. Eksperimental'naia i klinicheskaia farmakologiia; 2010 Mar 2010.
Molekul research summary: https://molekul.io/research/brom-extra-20408420. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry