[Cytosine demethylation in the tyrosine hydroxylase gene promoter in the hypothalamus cells of the rat brain under the action of an aminoadamantane derivative Ladasten].
Vakhitova IuV, Sadovnikov SV, Iamidanov RS, Seredenin SB · 2006 · Genetika; 2006 Jul
Study findings
After a single Ladasten exposure, rat hypothalamic cells showed increased cytosine demethylation at selected regulatory sites of the tyrosine-hydroxylase gene. The authors proposed a connection with increased transcription.
- Population and setting
- Animal or animal-tissue experiments
- Evidence type
- Animal / experimental
- Preparation
- See the original report; formulation details require verification.
- Source language
- rus
- Title source
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
Study limitations
- Original full text and detailed methods have not been reviewed.
- Experimental findings do not establish human efficacy, dosing or long-term safety.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Source access and review scope
Indexed citation and English abstract checked.
Recorded source-check date: 2026-10-07. This date does not imply a completed systematic review.
Citation and original source
Original source: Vakhitova IuV, Sadovnikov SV, Iamidanov RS, Seredenin SB. [Cytosine demethylation in the tyrosine hydroxylase gene promoter in the hypothalamus cells of the rat brain under the action of an aminoadamantane derivative Ladasten]. Genetika; 2006 Jul 2006.
Molekul research summary: https://molekul.io/research/brom-extra-16915929. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry