Gene expression in human mesenchymal stem cell aging cultures: modulation by short peptides
Ashapkin V, Khavinson V, Shilovsky G, Linkova N, Vanuyshin B · 2020 · Mol Biol Rep 47(6):4323-4329. PMID 32399807
What does this source report?
AED, KED and KE changed expression of selected aging-related genes. Effects depended on peptide and culture-aging model; KED affected TNKS2 in opposite directions across models.
- Population and setting
- Human embryonic bone-marrow MSC line FetMSCs, aged in culture
- Evidence type
- In vitro
- Preparation
- See the original report; formulation details require verification.
- Source language
- English
- Title provenance
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
What are the limitations?
- Human-derived cells are not human clinical participants.
- Gene-expression changes do not establish improved cartilage repair, slower aging or safety.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Source access and review scope
Indexed abstract and citation checked via Europe PMC / PubMed; full methods and risk of bias not appraised.
Recorded source-check date: 2026-09-29. This date does not imply a completed systematic review.
Cite and trace this record
Original source: Ashapkin V, Khavinson V, Shilovsky G, Linkova N, Vanuyshin B. Gene expression in human mesenchymal stem cell aging cultures: modulation by short peptides Mol Biol Rep 47(6):4323-4329. PMID 32399807 2020.
Molekul research summary: https://molekul.io/research/bio-32399807. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entryRelated compound profiles
Cartalax
AED research is distinct from PCC. The linked animal and cell papers, and a small patent-reported human comparison, do not establish cartilage regeneration.
Vilon
A peptide research entry in the Khavinson evidence map. Direct studies, related extract findings, institute reports and unresolved claims are distinguished below.
Vesugen
A peptide research entry in the Khavinson evidence map. Direct studies, related extract findings, institute reports and unresolved claims are distinguished below.
KED
A tripeptide research entry connected to experimental neurodegeneration work. No human benefit is inferred from mouse-model findings.