[Experimental and clinical data on the ability of bemetil to penetrate the hemato-encephalic barrier].
Boĭko SS, Bobkov IuG, Dobrokhotova TA, Kniazeva NA, Neznamov GG · 1987 · Farmakologiia i toksikologiia; 1987 May-Jun
Study findings
Bemitil concentrations exceeded plasma concentrations in rat brain tissue. In brain-injury patients, cerebrospinal-fluid concentrations were below plasma concentrations. The two measurements do not establish equivalent human brain exposure.
- Population and setting
- Rat tissue and human cerebrospinal-fluid measurements
- Evidence type
- Analytical / composition study
- Preparation
- See the original report; formulation details require verification.
- Source language
- rus
- Title source
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
Study limitations
- Full text and detailed methods have not been independently assessed.
- Pharmacokinetic or analytical measurements do not establish clinical efficacy or a safe dosing regimen.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Source access and review scope
Indexed citation and English abstract checked.
Recorded source-check date: 2026-10-07. This date does not imply a completed systematic review.
Citation and original source
Original source: Boĭko SS, Bobkov IuG, Dobrokhotova TA, Kniazeva NA, Neznamov GG. [Experimental and clinical data on the ability of bemetil to penetrate the hemato-encephalic barrier]. Farmakologiia i toksikologiia; 1987 May-Jun 1987.
Molekul research summary: https://molekul.io/research/bemitil-extra-3609285. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry