Chlorobenzoylaminoadamantane formulation for physical performance at high and low temperatures
Authors not yet confirmed · 2019 · RU2704126C2; filed 28 November 2016
What does this source report?
The patent reports longer treadmill endurance with the Chlodantane formulation under heat and cold. In heat, the selected comparison was 56.23 ± 5.36 versus 27.69 ± 1.31 minutes in controls. Ladasten showed a heat signal at the higher tested exposure but no significant cold-endurance benefit.
- Population and setting
- Male mice; treadmill tests at +40°C and −5°C
- Evidence type
- Patent / reported experiments
- Preparation
- See the original report; formulation details require verification.
- Source language
- Russian
- Title provenance
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
What are the limitations?
- Patent-reported animal results are not an independently replicated clinical trial or evidence of safe heat/cold exposure.
- The response was non-linear; formulation-specific effects cannot be assigned to every Chlodantane product.
- Small groups and inconsistent comparator sample reporting require original-table appraisal.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Patent
Review depth: Selected animal experiments and formulation description reviewed
Source access and review scope
Selected source passages checked; complete methods and risk of bias not appraised.
Recorded source-check date: 2026-10-03. This date does not imply a completed systematic review.
Cite and trace this record
Original source: Author unconfirmed. Chlorobenzoylaminoadamantane formulation for physical performance at high and low temperatures RU2704126C2; filed 28 November 2016 2019.
Molekul research summary: https://molekul.io/research/adk-chlodantane-2019-patent. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entryRelated compound profiles
Chlodantane
N-(adamantan-2-yl)-4-chlorobenzamide, an experimental benzamide from the Russian adamantane programme. Its amide linkage distinguishes it from Bromantane’s arylamine.
Bromantane
An adamantane-derived small molecule, also known as Ladasten. The expanded archive connects clinical asthenia studies, operator experiments and preclinical mechanisms, with model-specific limitations and safety findings.
Bemitil
A benzimidazole-derived actoprotector, also indexed as bemethyl and Metaprot. Research spans patient asthenia, occupational settings, neuromuscular and liver studies, metabolism and preclinical safety; these are research contexts, not established uses.