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Effects of iEW synthetic peptide isomers on bone marrow colony-forming capacity in vivo.

O. V. Semina, T. N. Semenets, I. A. Zamulaeva, E. I. Selivanova, Ya. V. Malyutina, Yu. A. Semin, V. I. Deigin, A. S. Saenko · 2005 · Bulletin of Experimental Biology and Medicine. 140(3):348–351

Animal / experimentalEnglish abstractSource linked

This is Molekul’s research summary, not the original publication. Educational information only, not medical advice. Seek qualified healthcare help for medical conditions.

What does this source report?

Experiments with peptide isomers and neuraminidase linked differing colony-forming responses to the T-cell microenvironment. The authors proposed shared CD34-associated surface interactions.

Population and setting: Mice; splenic colony-forming, CD34-positive-cell and T-cell assays
Evidence type: Animal / experimental
Preparation: Related L- and D-iEW isomers; preparation equivalence is not inferred
Source language: English
Title provenance: Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.

What are the limitations?

Mechanistic interpretation does not establish CD34 as a directly bound receptor.
Related-isomer experiments do not prove clinical effects of either marketed preparation.
Colony formation is not proof of long-term self-renewing stem-cell expansion.

Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.

Document format: Journal article

Review depth: Indexed abstract reviewed

Source access and review scope

Original publication metadata and indexed abstract checked; full methods and tables not appraised.

Recorded source-check date: 2026-10-03. This date does not imply a completed systematic review.

Open original source or index record ↗

DOI: 10.1007/s10517-005-0487-8

Cite and trace this record

Original source: O. V. Semina, T. N. Semenets, I. A. Zamulaeva, E. I. Selivanova, Ya. V. Malyutina, Yu. A. Semin, V. I. Deigin, A. S. Saenko. Effects of iEW synthetic peptide isomers on bone marrow colony-forming capacity in vivo. Bulletin of Experimental Biology and Medicine. 140(3):348–351 2005.

Molekul research summary: https://molekul.io/research/gaps-16307056. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.

Bibliography entry

Related compound profiles

Stemokin / Neogen

Synthetic Ile–Glu–Trp tripeptide (IEW), studied in hematopoietic experiments and Russian clinical immune research. It is distinct from whole tissue extracts.

Thymodepressin

Synthetic Glu–Trp-derived dipeptide in the suppressive branch of this research program. Stereochemistry and peptide-bond position matter.

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