COMPOUND RECORD / MOTS-C

MOTS-cМитокин MOTS-c

PerformanceStressRecovery

Source linked

01 / OVERVIEW

About MOTS-c

Names in this research collection

MOTS-c mitokine · MOTS-c mitochondrial peptide

A short mitochondrial-derived peptide. The Russian space-medicine study examined whether it preserved soleus muscle function during seven days of hindlimb unloading.

Research background

A short mitochondrial-derived peptide. The Russian space-medicine study examined whether it preserved soleus muscle function during seven days of hindlimb unloading.

What the studies found

Animal research · 2025

Who or what was studiedMale Wistar rats undergoing seven days of hindlimb suspension; final fatigue test in excised soleus muscle

Reported finding

MOTS-c preserved isolated soleus fatigue resistance and mitigated slow-fiber atrophy. Fast-fiber atrophy was not mitigated.

Ex vivo soleus fatigue: Increase in fatigue with unloading was prevented in the treated groupAfter 7 days; numerical effect size unavailable in the abstract.
Fiber-type changes: Attenuated slow-fiber atrophy and slow-to-fast shift; fast-fiber atrophy not preventedHistology; absolute cross-sectional areas not verified.
Signaling and ribosomal RNA: Preserved Akt/GSK3β phosphorylation and 18S/28S rRNA near control levelsBiochemical measures in rat soleus.

All reported results & study design →

Methods, dose & source notes

Study of this preparation · Original journal article

Original numerical fatigue effect and group sizes require full text. Ex vivo muscle function after disuse differs from athletic endurance in an exercising person. Several molecular readouts do not establish one causal pathway.

MOTS-c during seven days of rat hindlimb unloading ↗

These highlights cover selected studies. Open a source for its methods, reported doses and full context.

Performance research in context

Sports performance evidence map ↗ Military & occupational evidence map ↗

Compound class: Mitochondrial-derived peptide
Research collection: Actoprotection & occupational pharmacology · editorial grouping
Research institutions: No institutional affiliation recorded
Source review: Review dates and the material assessed are listed with each publication below.

02 / HOW TO READ THE RESEARCH

Understanding the evidence

Human research No human intervention in this study.
Study methods Rat disuse model, daily injections and ex vivo fatigue measurement; original full article unavailable for dose and effect-size verification.
Independent replication Independent replication is not established in the linked sources.
Source access Original sources and the exact review scope are linked below.
Safety evidence The linked experiments do not establish a safe human performance regimen.

Open a topic for the evidence assessment.

More findings, background and history

EVIDENCE REVIEW / 6 OCTOBER 2026

Outstanding review questions

Appraise original methods and replication; keep animal and cell findings separate from unestablished human benefit and safety.

No human intervention report has been identified among the linked records; unclassified archival leads may remain. Publication records can share participants. Source counts are not trial counts.

Browse original study records ↗

03 / SOURCE RECORDS

Linked sources

Explore the research map and unresolved leads ↗

2025 · MOTS-c during seven days of rat hindlimb unloadingEx vivo soleus fatigue: Increase in fatigue with unloading was prevented in the treated group

2025Animal / experimentalEnglish abstract

MOTS-c during seven days of rat hindlimb unloading

· Original journal article

Format: Publisher abstract and PubMed record checked; subscription PDF, numerical figures and complete treatment methods not recovered · Reviewed: Reported methods, results and evidence limitations

D. A. Sidorenko, I. D. Lvova, S. A. Tyganov, B. S. Shenkman, K. A. Sharlo · J Muscle Res Cell Motil. 46(3):215–229; PMID 40608240

MOTS-c preserved isolated soleus fatigue resistance and mitigated slow-fiber atrophy. Fast-fiber atrophy was not mitigated.

Findings, study figures and available tables

Reported findings and study design

MOTS-c preserved isolated soleus fatigue resistance and mitigated slow-fiber atrophy. Fast-fiber atrophy was not mitigated.

Male Wistar rats undergoing seven days of hindlimb suspension; final fatigue test in excised soleus muscle

Protocol information

Daily intraperitoneal injections during seven days of unloading. Dose and group-level denominators are not given in the verified abstract.

Protocol source ↗ · Publisher abstract and PubMed record checked; subscription PDF, numerical figures and complete treatment methods not recovered

Reported findings and study figures · Publisher abstract and PubMed record checked; subscription PDF, numerical figures and complete treatment methods not recovered
Measure	Result	Comparison, timing and statistics
Ex vivo soleus fatigue	Increase in fatigue with unloading was prevented in the treated group	After 7 days; numerical effect size unavailable in the abstract.
Fiber-type changes	Attenuated slow-fiber atrophy and slow-to-fast shift; fast-fiber atrophy not prevented	Histology; absolute cross-sectional areas not verified.
Signaling and ribosomal RNA	Preserved Akt/GSK3β phosphorylation and 18S/28S rRNA near control levels	Biochemical measures in rat soleus.
Atrophy and mitochondrial markers	Lower MuRF and Atrogin-1 mRNA; preservation of selected biogenesis markers and ACC phosphorylation	Compared with unloaded placebo animals; no causal mediation established.

A muscle-disuse preservation experiment, relevant to space medicine and immobilization. The abstract does not establish human protection or an ergogenic effect.

Source for the extracted data ↗ · Checked 2026-11-08

Population / setting: Male Wistar rats undergoing seven days of hindlimb suspension; final fatigue test in excised soleus muscle
What was checked: Publisher abstract and PubMed record checked; subscription PDF, numerical figures and complete treatment methods not recovered

Limitations & review scope

Original numerical fatigue effect and group sizes require full text.
Ex vivo muscle function after disuse differs from athletic endurance in an exercising person.
Several molecular readouts do not establish one causal pathway.

Source checked 2026-11-08. See the review scope above for the material assessed.

Read the source ↗

Research collection curated by @PepMariner · editorial standards. Send a source correction ↗

Browse bibliography & PDFs ↗