Molecular aspects of immunoprotective activity of peptides in spleen during the ageing process
Сhervyakova NA, Linkova NS, Chalisova NI, Koncevaya EA, Trofimova SV, Khavinson VK · 2014 · Advances in gerontology = Uspekhi gerontologii 2014
Reported findings and study design
Crystagen activated B-cell measures but did not cause renewal of the aging spleen. Vilon was associated with lower T-helper-cell apoptosis; Thymogen with lower apoptosis and increased B-cell proliferation.
Experimental aging-spleen work; species and assay design not specified in the indexed abstract.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Crystagen response | B-cell activation reported; no aging-spleen cell renewal | |
| Other peptide responses | Vilon: reduced T-helper apoptosis; Thymogen: B-cell proliferation with less apoptosis |
The abstract does not establish the experimental model sufficiently to classify this as a human study or a specific animal/cell design. Commercial product equivalence is unverified.
Source for the extracted data ↗ · Checked 2026-11-01
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- The abstract does not establish the experimental model sufficiently to classify this as a human study or a specific animal/cell design. Commercial product equivalence is unverified.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Indexed abstract checked
Source access and review scope
Original-publication metadata and indexed abstract checked in Europe PMC. No unavailable full-text figures inferred.
Recorded source-check date: 2026-11-01. This date does not imply a completed systematic review.
Source type: Journal publication
Citation and original source
Original source: Сhervyakova NA, Linkova NS, Chalisova NI, Koncevaya EA, Trofimova SV, Khavinson VK. Molecular aspects of immunoprotective activity of peptides in spleen during the ageing process Advances in gerontology = Uspekhi gerontologii 2014 2014.
Molekul research summary: https://molekul.io/research/thin-28976144. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entryRelated compound profiles
Crystagen
A product named in the originating-institute clinical-report collection. Experimental sequence, marketed formulation and clinical preparation must be checked separately.
Vilon
Defined Lys–Glu (KE) dipeptide with historical adjunct-treatment reports in type 1 diabetes and separate laboratory research. Immune and coagulation-marker findings do not establish autoimmune disease modification.
Thymogen
EW is discussed in the thymus-derived research program. Thymalin extract outcomes cannot be assigned to this defined peptide.