Peptides tissue-specifically stimulate cell differentiation during their aging
Khavinson VKh, Linkova NS, Polyakova VO, Kheifets OV, Tarnovskaya SI, Kvetnoy IM · 2012 · Bulletin of experimental biology and medicine 2012
Reported findings and study design
Pancragen increased differentiation-marker expression in pancreatic cells, Bronchogen in bronchial cells, and Vesugen in prostatic fibroblasts. Responses were more pronounced in aged cultures.
Human embryonic pancreatic and bronchial cell cultures, plus human prostatic fibroblasts, compared at different passage ages.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Differentiation markers | CXCL12/Hoxa3 or CXCL12/WEGC1 expression increased in the corresponding cultures | |
| Preparation assignments | Pancragen KEDW → pancreas; Bronchogen AEDL → bronchial cells; Vesugen KED → prostatic fibroblasts |
Different peptides were tested in different cell types; this is not a combination trial or evidence of organ recovery in patients. No numerical effect sizes are supplied.
Source for the extracted data ↗ · Checked 2026-11-01
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Different peptides were tested in different cell types; this is not a combination trial or evidence of organ recovery in patients. No numerical effect sizes are supplied.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Indexed abstract checked
Source access and review scope
Original-publication metadata and indexed abstract checked in Europe PMC. No unavailable full-text figures inferred.
Recorded source-check date: 2026-11-01. This date does not imply a completed systematic review.
Source type: Journal publication
Citation and original source
Original source: Khavinson VKh, Linkova NS, Polyakova VO, Kheifets OV, Tarnovskaya SI, Kvetnoy IM. Peptides tissue-specifically stimulate cell differentiation during their aging Bulletin of experimental biology and medicine 2012 2012.
Molekul research summary: https://molekul.io/research/thin-22808515. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entryRelated compound profiles
Pancragen
A peptide research entry in the Khavinson evidence map. Direct studies, related extract findings, institute reports and unresolved claims are distinguished below.
Bronchogen
AEDL tetrapeptide studied in bronchial cells, rat lung-injury models and a 78-patient oral-capsule comparison. The clinical report includes lung-volume measurements over 30 days.
Vesugen
A peptide research entry in the Khavinson evidence map. Direct studies, related extract findings, institute reports and unresolved claims are distinguished below.