Safety and Efficacy of Cerebrolysin for Neurorecovery After Acute Ischemic Stroke: A Systematic Review and Meta-Analysis of 14 Randomized Controlled Trials

Patel PN, Mangal D, Patel K · 2025 · Cureus · PMID 41018475

ReviewEnglish abstractSource linked

This is Molekul’s research summary, not the original publication. Educational information only, not medical advice. Seek qualified healthcare help for medical conditions.

What does this source report?

The review reports a neurological-scale benefit, but functional independence and mortality were not significantly improved.

Population and setting: 2025 meta-analysis reporting 14 randomized trials
Evidence type: Review
Preparation: See the original report; formulation details require verification.
Source language: English
Title provenance: Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.

What are the limitations?

The abstract calls hemorrhagic transformation nonsignificant despite a confidence interval excluding the null.
The included-publication list contains both CARS and a pooled CARS report; cohort independence needs reconciliation.
Numerical pooled estimates are withheld here pending appraisal of these reporting issues.

Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.

Review depth: Abstract reviewed

Source access and review scope

Indexed abstract and publicly indexed methods checked; inconsistencies flagged, not independently resolved.

Recorded source-check date: 2026-10-05. This date does not imply a completed systematic review.

Open original source or index record ↗

DOI: 10.7759/cureus.91054

Cite and trace this record

Original source: Patel PN, Mangal D, Patel K. Safety and Efficacy of Cerebrolysin for Neurorecovery After Acute Ischemic Stroke: A Systematic Review and Meta-Analysis of 14 Randomized Controlled Trials Cureus · PMID 41018475 2025.

Molekul research summary: https://molekul.io/research/stroke-41018475. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.

Bibliography entry

Related compound profiles

Cerebrolysin

Porcine brain-derived peptide mixture studied in neurological disease, rehabilitation and laboratory models. Clinical results, composition analyses and unresolved archival leads are separated in this collection.

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