Design, synthesis, and neuroprotective effects of a dimeric dipeptide mimetic of the third loop of the nerve growth factor
Authors not yet confirmed · 2017 · Primary source linked above
What does this source report?
GTS-113 and GTS-115 were designed from NGF loop 3. GTS-115 showed cell protection and reduced infarct volume in a rat stroke model, but also induced hyperalgesia.
- Population and setting
- Cultured cells and rat ischemia/pain models
- Evidence type
- Animal / experimental
- Preparation
- See the original report; formulation details require verification.
- Source language
- See source; English abstract or translated patent text where available
- Title provenance
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
What are the limitations?
- Publisher abstract reviewed; full methods pending.
- Animal efficacy and pain responses do not establish human benefit or safety.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Selected text reviewed
Source access and review scope
Selected original-source text checked; full methodological review pending.
Recorded source-check date: 2026-10-05. This date does not imply a completed systematic review.
Cite and trace this record
Original source: Author unconfirmed. Design, synthesis, and neuroprotective effects of a dimeric dipeptide mimetic of the third loop of the nerve growth factor Primary source linked above 2017.
Molekul research summary: https://molekul.io/research/rp-gts115-2017. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry