Structural and cytochemical changes in cerebral cortical neurons of the offspring of neurosensitized female rats after prenatal administration of thymalin
Kazakova PB, Konokotina GF · 1989 · Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952). 1989;89(7):114. PMID 2800803
Maternal exposure in animals · Pregnancy and offspring evidence review ↗
Reported findings and study design
Narrative findings; numerical extraction incomplete
Maternal Thymalin reportedly prevented cortical neuronal degeneration and cell-density loss in offspring, with age-dependent protein changes. No numerical effect sizes or reproductive-safety outcomes are supplied.
Gestational Thymalin course in neurosensitized dams, followed by age-related cortical histology/cytochemistry in offspring.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Cortical histology | Less dystrophic change, neuronal death and reduced cortical cell density described | |
| Cellular protein | Higher nuclear and especially cytoplasmic protein content; effects reportedly stronger in older offspring |
Qualitative historical animal abstract; no verified group size, dose, allocation or quantitative histological effect. Disease-model cortical findings do not establish fetal safety, placental transfer or clinical benefit in pregnancy.
Source for the extracted data ↗ · Checked 2026-11-08
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Qualitative historical animal abstract; no verified group size, dose, allocation or quantitative histological effect.
- Disease-model cortical findings do not establish fetal safety, placental transfer or clinical benefit in pregnancy.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Publication record and available text
Review depth: Indexed original abstract; full methods and outcome tables not recovered
Related-report group: pregnancy-thymalin-maternal-1989. Reports in this group are not assumed to be independent trials.
Source access and review scope
Indexed original abstract; full methods and outcome tables not recovered
Recorded source-check date: 2026-11-08. This date does not imply a completed systematic review.
Source type: Original journal publication
Citation and original source
Original source: Kazakova PB, Konokotina GF. Structural and cytochemical changes in cerebral cortical neurons of the offspring of neurosensitized female rats after prenatal administration of thymalin Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952). 1989;89(7):114. PMID 2800803 1989.
Molekul research summary: https://molekul.io/research/pregnancy-thymalin-maternal-1989. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry