Peptidergic correction of the effect of acute hypobaric hypoxia in pregnant rats on progeny
Maslova MV, Zemlyanskii KS, Shkol'nikova MV, Maklakova AS, Krushinskaya YV, Sokolova NA, Ashmarin IP · 2001 · Bulletin of experimental biology and medicine. 2001;131(2):109. PMID 11391386
Maternal exposure in animals · Pregnancy and offspring evidence review ↗
Reported findings and study design
Narrative findings; numerical extraction incomplete
Maternal Semax plus β-casomorphin-7 reportedly prevented delayed pup growth, weight gain, eye opening and behavioral changes after acute hypoxia. The checked abstract provides no numerical effect sizes.
Maternal intranasal peptide exposure around an acute prenatal hypoxic insult; postnatal growth/behavior or brain monoamines evaluated.
Dose, route and schedule
Intranasal maternal peptide exposure. The 2003 abstract specifies a single administration; doses and exact exposure timing are not supplied in the checked abstracts.
Protocol source ↗ · Indexed original abstract; full methods and outcome tables not recovered
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Growth and eye opening | Delayed by hypoxia; authors report prevention with the peptide mixture | |
| Behavior | Hypoxia-associated changes reportedly prevented; exact tests and scores not supplied |
The 2001 intervention is explicitly a Semax plus β-casomorphin-7 mixture; the 2003 abstract does not isolate compound-specific effects. No verified sample sizes, effect magnitudes, randomization, masking or systematic reproductive-safety assessment in the checked abstract. Related papers from one laboratory do not establish independent replication or human pregnancy safety.
Source for the extracted data ↗ · Checked 2026-11-08
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- The 2001 intervention is explicitly a Semax plus β-casomorphin-7 mixture; the 2003 abstract does not isolate compound-specific effects.
- No verified sample sizes, effect magnitudes, randomization, masking or systematic reproductive-safety assessment in the checked abstract.
- Related papers from one laboratory do not establish independent replication or human pregnancy safety.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Publication record and available text
Review depth: Indexed original abstract; full methods and outcome tables not recovered
Related-report group: msu-maslova-prenatal-hypoxia. Reports in this group are not assumed to be independent trials.
Source access and review scope
Indexed original abstract; full methods and outcome tables not recovered
Recorded source-check date: 2026-11-08. This date does not imply a completed systematic review.
Source type: Original journal publication
Citation and original source
Original source: Maslova MV, Zemlyanskii KS, Shkol'nikova MV, Maklakova AS, Krushinskaya YV, Sokolova NA, Ashmarin IP. Peptidergic correction of the effect of acute hypobaric hypoxia in pregnant rats on progeny Bulletin of experimental biology and medicine. 2001;131(2):109. PMID 11391386 2001.
Molekul research summary: https://molekul.io/research/pregnancy-semax-mixture-2001. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry