Studying the Toxic Effects of Some Biologically Active Peptides on the Model of Mouse Embryonic Stem Cells
Kobylyanskii AG, Zolotarev YA, Andreeva LA, Grivennikov IA, Myasoedov NF · 2017 · Bulletin of experimental biology and medicine. 2017;163(6):731. PMID 29063333
Embryonic-cell experiments · Pregnancy and offspring evidence review ↗
Reported findings and study design
Reported findings
Selank at 100 µM reduced the GABA-positive neuron ratio by 61% versus control. Semax improved cell survival under serum deprivation, while PGP modestly inhibited proliferation at 10 µM. Cell findings cannot substantiate the abstract’s broad fetal-safety conclusion.
Cultured mouse embryonic stem cells; proliferation, survival during serum deprivation and neuronal differentiation after several peptides and growth-factor controls.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Selank neuronal differentiation | GABA-positive neuron ratio decreased by 61% | Selank 100 µM versus control; not an in-vivo malformation endpoint |
| PGP proliferation | Small but significant inhibition at 10 µM | No numerical inhibition magnitude in abstract |
| Semax cell survival | Increased survival at 10 and 0.1 µM during serum deprivation | Cell-stress endpoint, not reproductive toxicology |
| Safety-inference limit | The authors infer no embryonic/fetal toxicity; this culture model does not establish that claim in pregnancy |
Embryonic-cell experiments do not test placental exposure, whole-embryo development, birth defects or pregnancy outcomes. Reduced differentiation and proliferation findings must not be omitted from a safety summary. Concentrations in a culture dish are not human doses; biological replicate counts and complete numerical results absent from the checked abstract.
Source for the extracted data ↗ · Checked 2026-11-08
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Embryonic-cell experiments do not test placental exposure, whole-embryo development, birth defects or pregnancy outcomes.
- Reduced differentiation and proliferation findings must not be omitted from a safety summary.
- Concentrations in a culture dish are not human doses; biological replicate counts and complete numerical results absent from the checked abstract.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Publication record and available text
Review depth: Indexed original abstract; full methods and outcome tables not recovered
Related-report group: pregnancy-peptide-embryonic-cells-2017. Reports in this group are not assumed to be independent trials.
Source access and review scope
Indexed original abstract; full methods and outcome tables not recovered
Recorded source-check date: 2026-11-08. This date does not imply a completed systematic review.
Source type: Original journal publication
Citation and original source
Original source: Kobylyanskii AG, Zolotarev YA, Andreeva LA, Grivennikov IA, Myasoedov NF. Studying the Toxic Effects of Some Biologically Active Peptides on the Model of Mouse Embryonic Stem Cells Bulletin of experimental biology and medicine. 2017;163(6):731. PMID 29063333 2017.
Molekul research summary: https://molekul.io/research/pregnancy-peptide-embryonic-cells-2017. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entryRelated compound profiles
Semax
ACTH-fragment-derived peptide with clinical stroke and optic-nerve reports, healthy-volunteer imaging and preclinical neuroregulation research. Precursor, patent and dissertation sources remain separately labeled.
Selank
Tuftsin-derived peptide investigated in anxiety comparisons, stress models and neurochemical assays. Its clinical and laboratory evidence are kept distinct from unverified archival claims.
Glyprolins & PGP hybrids
A family record separating simple Pro/Gly peptides, PGP-containing hybrids and proposed protein-fragment lineages.