NALE and Hydra morphogen: maternal exposure and offspring lung findings
O. A. Lebedko · 1994 · Candidate dissertation author’s abstract. Khabarovsk, 1994; respiratory-system DNA synthesis and lipid peroxidation after prenatal hypoxia
Maternal exposure in animals · Pregnancy and offspring evidence review ↗
Reported findings and study design
Reported findings
Maternal non-opioid Leu-enkephalin analogue exposure reportedly restored offspring tracheal DNA synthesis after prenatal hypoxia and changed lung redox measures. The distinct Hydra morphogen inhibited tracheal DNA synthesis in uninjured offspring. Sequence transcription and full-thesis tables need authentication.
Four exposure conditions for each peptide: uninjured, prenatal hypoxia, peptide alone, peptide plus hypoxia. Daily maternal hypoxia on gestation days 14–19; offspring examined 24 hours after birth. Separate non-opioid analogue and Hydra morphogen arms.
Dose, route and schedule
Non-opioid Leu-enkephalin analogue or Hydra peptide morphogen 10 µg/kg intraperitoneally to dams 30 minutes before daily hypoxic exposure on gestation days 14–19. Day-1 offspring tracheal DNA-synthesis and lung/blood redox assays. Experimental methods, not a human pregnancy regimen.
Protocol source ↗ · Medical-Diss author-abstract transcription; selected methods, narrative results and source limitations checked; original full thesis not recovered
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Non-opioid analogue plus hypoxia | Offspring tracheal DNA synthesis reportedly restored; neonatal lung catalase and superoxide-dismutase activity reportedly returned toward control levels | Qualitative/narrative extraction; per-group n and precise uncertainty not authenticated |
| Hydra morphogen alone: adverse direction | Tracheal epithelial DNA synthesis and part of antioxidant defense were suppressed in uninjured offspring | This is a different experimental peptide, not an effect assigned to NALE |
| Neutral assay findings | Glutathione reductase and glutathione transferase did not differ significantly across experimental groups | No universal improvement across all antioxidant endpoints |
Historical maternal animal study; no human pregnancy efficacy or safety established. Third-party OCR transcription, not an authenticated 147-page thesis. Tables and peptide sequences contain OCR ambiguity; no precise table cells are treated as visually verified. NALE is a non-opioid analogue, distinct from Dalargin. The transcription prints a third residue resembling Glu, while later NALE sources specify Gly; exact preparation identity remains unresolved. The associated 1994 journal report may share these experiments and must not be counted as independent replication. Hydra morphogen has no interchangeable compound-card assignment.
Source for the extracted data ↗ · Checked 2026-11-08
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Historical maternal animal study; no human pregnancy efficacy or safety established.
- Third-party OCR transcription, not an authenticated 147-page thesis. Tables and peptide sequences contain OCR ambiguity; no precise table cells are treated as visually verified.
- NALE is a non-opioid analogue, distinct from Dalargin. The transcription prints a third residue resembling Glu, while later NALE sources specify Gly; exact preparation identity remains unresolved.
- The associated 1994 journal report may share these experiments and must not be counted as independent replication. Hydra morphogen has no interchangeable compound-card assignment.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Dissertation author-abstract transcription
Review depth: Medical-Diss author-abstract transcription; selected methods, narrative results and source limitations checked; original full thesis not recovered
Related-report group: khabarovsk-nale-prenatal-1994. Reports in this group are not assumed to be independent trials.
Source access and review scope
Medical-Diss author-abstract transcription; selected methods, narrative results and source limitations checked; original full thesis not recovered
Recorded source-check date: 2026-11-08. This date does not imply a completed systematic review.
Source type: Dissertation author-abstract transcription
Citation and original source
Original source: O. A. Lebedko. NALE and Hydra morphogen: maternal exposure and offspring lung findings Candidate dissertation author’s abstract. Khabarovsk, 1994; respiratory-system DNA synthesis and lipid peroxidation after prenatal hypoxia 1994.
Molekul research summary: https://molekul.io/research/pregnancy-nale-thesis-1994. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry