Spruce polyprenols in a mouse demyelination model
M. Y. Khodanovich, A. O. Pishchelko, V. Y. Glazacheva, E. S. Pan, E. P. Krutenkova, V. B. Trusov, V. L. Yarnykh · 2019 · Phytotherapy Research. 33(5):1363–1373
Reported findings and study design
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Animals and histology | 27 allocated, nine per group; histology examined seven per group. | |
| Myelin and cell markers | The treated group had greater myelin-basic-protein signal than the toxin-exposed vehicle group; selected precursor-cell and immature-neuron markers also differed. |
The design does not isolate remyelination from protection against continued injury, and it is not a human MS treatment study.
Source for the extracted data ↗ · Checked 2026-11-06
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- A toxin-induced demyelination model does not establish control of autoimmune disease or clinical benefit in multiple sclerosis.
- The authors could not distinguish protection against continuing damage from enhanced repair; remyelination was not isolated as the mechanism.
- One endpoint time and no polyprenol-only healthy control limit interpretation.
- Twenty-seven animals were allocated, while histology used seven per group. The selected methods passage does not explain this subset.
- Experimental injection is not equivalent to oral Ropren exposure in humans; nonsignificance against healthy controls is not proof of equivalence.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Complete original open-access XML recovered through Europe PMC
Review depth: Methods, results narrative and stated limitations checked; graph values not visually transcribed
Source access and review scope
Original methods and results; random group allocation, blinded histology/image analysis and multiplicity-adjusted comparisons described.
Recorded source-check date: 2026-11-06. This date does not imply a completed systematic review.
Source type: Original preclinical research; Shustov is not an author
Open original source or index record ↗
DOI: 10.1002/ptr.6327
Citation and original source
Original source: M. Y. Khodanovich, A. O. Pishchelko, V. Y. Glazacheva, E. S. Pan, E. P. Krutenkova, V. B. Trusov, V. L. Yarnykh. Spruce polyprenols in a mouse demyelination model Phytotherapy Research. 33(5):1363–1373 2019.
Molekul research summary: https://molekul.io/research/polyprenols-myelin-2019. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry