Acute and delayed effects of DSIP (delta sleep-inducing peptide) on human sleep behavior
Schneider-Helmert D, Gnirss F, Monnier M, Schenker J, Schoenenberger GA · 1981 · Int J Clin Pharmacol Ther Toxicol 19:341-345
Reported findings and study design
In a double-blind crossover experiment, median total sleep time during the 130-minute post-infusion interval was 59% higher with DSIP than placebo. This was an acute sleep experiment in six healthy volunteers.
Dose, route and schedule
Slow morning intravenous DSIP infusion, 25 nmol/kg, versus placebo. Historical study methods, not personal-use instructions.
Protocol source ↗ · Indexed abstract
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Median total sleep time | 59% higher than placebo | 130-minute post-infusion interval |
| Participants | 6 healthy volunteers |
No absolute sleep-duration values or confidence interval are provided in the abstract. A six-person experiment cannot establish long-term insomnia treatment effects.
Source for the extracted data ↗ · Checked 2026-11-01
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- No absolute sleep-duration values or confidence interval are provided in the abstract.
- A six-person experiment cannot establish long-term insomnia treatment effects.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Indexed abstract checked
Source access and review scope
Primary indexed abstract and publication metadata checked through Europe PMC on 1 November 2026. Full-text methods not reviewed.
Recorded source-check date: 2026-11-01. This date does not imply a completed systematic review.
Source type: Original journal report
Citation and original source
Original source: Schneider-Helmert D, Gnirss F, Monnier M, Schenker J, Schoenenberger GA. Acute and delayed effects of DSIP (delta sleep-inducing peptide) on human sleep behavior Int J Clin Pharmacol Ther Toxicol 19:341-345 1981.
Molekul research summary: https://molekul.io/research/placebo-6895513. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry