Cerebrolysin enhances cognitive recovery of mild traumatic brain injury patients: double-blind, placebo-controlled, randomized study
Chen CC, Wei ST, Tsaia SC, Chen XX, Cho DY · 2013 · Br J Neurosurg 27:803-807
Reported findings and study design
At 12 weeks, CASI cognitive-score improvement was 21.0 ± 20.4 points with Cerebrolysin versus 7.6 ± 12.1 with saline placebo (p=0.0461).
Dose, route and schedule
Cerebrolysin 30 mL intravenously daily over 60 minutes for five days; matched saline administration in controls. Historical study methods, not personal-use instructions.
Protocol source ↗ · Indexed abstract
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| CASI change from baseline | 21.0 ± 20.4 versus 7.6 ± 12.1 points | 12 weeks · p=0.0461 |
| Drawing and long-term memory | Selected domain differences favored Cerebrolysin | Drawing week 4 p=0.0066; drawing week 12 p=0.0472; memory week 12 p=0.0256 |
Small phase II pilot with several cognitive tests and timepoints. This does not establish benefit across all brain injuries.
Source for the extracted data ↗ · Checked 2026-11-01
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Small phase II pilot with several cognitive tests and timepoints. This does not establish benefit across all brain injuries.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Indexed abstract checked
Source access and review scope
Primary indexed abstract and publication metadata checked through Europe PMC on 1 November 2026. Full-text methods not reviewed.
Recorded source-check date: 2026-11-01. This date does not imply a completed systematic review.
Source type: Original journal report
Citation and original source
Original source: Chen CC, Wei ST, Tsaia SC, Chen XX, Cho DY. Cerebrolysin enhances cognitive recovery of mild traumatic brain injury patients: double-blind, placebo-controlled, randomized study Br J Neurosurg 27:803-807 2013.
Molekul research summary: https://molekul.io/research/placebo-23656173. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry