Phenotropil and piracetam in a Russian chronic fatigue comparison
V. I. Akhapkina; A. I. Fedin; A. S. Avedisova; R. V. Akhapkin · 2006 · MEDI.RU author report, March 2006
Indexed 2026-11-12.
Reported findings and study design
Reported findings
Four-week oral comparison. Phenotropil started at 50 mg twice daily and was titrated to 200–250 mg/day. Piracetam was 400 mg three times daily. Placebo mimicked the Phenotropil regimen.
Dose, route and schedule
Four-week oral comparison. Phenotropil started at 50 mg twice daily and was titrated to 200–250 mg/day. Piracetam was 400 mg three times daily. Placebo mimicked the Phenotropil regimen.
Protocol source ↗ · Original source
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Complete or partial symptom response in the CFS subgroup | 28/32 (87.5%) with Phenotropil and 11/20 (55%) with piracetam. The authors reported p<0.05 for the drug comparison. | |
| Placebo | The authors report no complete response. The narrative gives no matching count for partial response. |
The dossier does not establish random allocation, assessor masking or a modern case definition requiring PEM. The authors’ criteria describe symptom relief over four weeks.
Source for these results ↗ · Reviewed 2026-11-12
For research and education. Consult a qualified clinician for medical advice.
Study limitations and source details
Study limitations
- The dossier does not establish random allocation, assessor masking or a modern case definition requiring PEM. The authors’ criteria describe symptom relief over four weeks.
Source access
Four-week oral comparison. Phenotropil started at 50 mg twice daily and was titrated to 200–250 mg/day. Piracetam was 400 mg three times daily. Placebo mimicked the Phenotropil regimen.
Source reviewed 2026-11-12.
Citation and original source
Original source: V. I. Akhapkina; A. I. Fedin; A. S. Avedisova; R. V. Akhapkin. Phenotropil and piracetam in a Russian chronic fatigue comparison MEDI.RU author report, March 2006 2006.
Molekul research summary: https://molekul.io/research/phenotropil-piracetam-cfs-2006. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entryRelated compound profiles
Phenotropil
A phenyl-substituted piracetam analogue connecting early Soviet experimental pharmacology, IMBP development and later clinical studies. Temperature-dependent animal findings, patient trials and healthy-volunteer PK studies address different questions.
Piracetam
Piracetam, marketed as Nootropil, connects the original nootropic concept with Soviet clinical adoption and later operator, hypoxia and maritime research. Healthy-volunteer experiments, clinical reviews and combination proposals answer different questions.