Noofen in chronic cerebrovascular insufficiency with fatigue
O. V. Vorobieva; V. V. Rusaya · 2017 · S. S. Korsakov Journal of Neurology and Psychiatry, 117(11), pp. 31–36
Indexed 2026-11-12.
Reported findings and study design
Reported findings
Six-week comparison. The authors report random assignment to oral phenibut hydrochloride 500 mg twice daily plus standard care, or standard care alone. The main measure was the MFI-20 fatigue score.
Dose, route and schedule
Six-week comparison. The authors report random assignment to oral phenibut hydrochloride 500 mg twice daily plus standard care, or standard care alone. The main measure was the MFI-20 fatigue score.
Protocol source ↗ · Original source
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Fatigue score | MFI-20 fell from 67.3±4.7 to 41.4±3.1 in the Noofen arm (within-arm p<0.001). Authors reported no change in usual care. | |
| Participants with 30–50% lower fatigue scores | 25/33 (75.8%) with add-on Noofen versus 5/20 (25%) with usual care. |
No placebo or masking is described. Chronic cerebral ischemia was required for inclusion. The trial measured fatigue in that population.
Source for these results ↗ · Reviewed 2026-11-12
For research and education. Consult a qualified clinician for medical advice.
Study limitations and source details
Study limitations
- No placebo or masking is described. Chronic cerebral ischemia was required for inclusion. The trial measured fatigue in that population.
Source access
Six-week comparison. The authors report random assignment to oral phenibut hydrochloride 500 mg twice daily plus standard care, or standard care alone. The main measure was the MFI-20 fatigue score.
Source reviewed 2026-11-12.
Citation and original source
Original source: O. V. Vorobieva; V. V. Rusaya. Noofen in chronic cerebrovascular insufficiency with fatigue S. S. Korsakov Journal of Neurology and Psychiatry, 117(11), pp. 31–36 2017.
Molekul research summary: https://molekul.io/research/phenibut-vorobieva-fatigue-2017. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry