COMPOUND RECORD / PHENIBUT

PhenibutФенибут

Recovery

Source linked

What the studies found

Comparison in people · 2017

Noofen in chronic cerebrovascular insufficiency with fatigue

Fatigue score: MFI-20 fell from 67.3±4.7 to 41.4±3.1 in the Noofen arm (within-arm p<0.001). Authors reported no change in usual care.

MFI-20 fell from 67.3±4.7 to 41.4±3.1 in the Noofen arm (within-arm p<0.001). Authors reported no change in usual care.

Study notes · methods, sources and limitations

Participants or model 53 people with chronic cerebral ischemia, fatigue and anxiety, 33 add-on Noofen and 20 usual care

Design Six-week comparison. The authors report random assignment to oral phenibut hydrochloride 500 mg twice daily plus standard care, or standard care alone. The main measure was the MFI-20 fatigue score.

Participants with 30–50% lower fatigue scores: 25/33 (75.8%) with add-on Noofen versus 5/20 (25%) with usual care.

Important limitations

No placebo or masking is described. Chronic cerebral ischemia was required for inclusion. The trial measured fatigue in that population.

S. S. Korsakov Journal of Neurology and Psychiatry, 117(11), pp. 31–36 · Publication record

Original source or citation ↗

Study results and tables ↗

01 / OVERVIEW

About Phenibut

Names in this research collection

Noofen · Ноофен · aminophenylbutyric acid

The linked Russian comparison measured fatigue in people with chronic cerebral ischemia taking Noofen alongside usual care.

Research background

The linked Russian comparison measured fatigue in people with chronic cerebral ischemia taking Noofen alongside usual care.

Russian ME/CFS and fatigue research ↗

Compound class: GABA analogue
Research collection: Russian ME/CFS and fatigue research · editorial grouping
Research institutions: No institutional affiliation recorded
Source review: Review dates and the material assessed are listed with each publication below.

02 / HOW TO READ THE RESEARCH

Understanding the evidence

Human research Noofen in chronic cerebrovascular insufficiency with fatigue (2017)
Study methods 53 people with chronic cerebral ischemia, fatigue and anxiety, 33 add-on Noofen and 20 usual care. Six-week comparison. The authors report random assignment to oral phenibut hydrochloride 500 mg twice daily plus standard care, or standard care alone. The main measure was the MFI-20 fatigue score.
Independent replication No placebo or masking is described. Chronic cerebral ischemia was required for inclusion. The trial measured fatigue in that population.
Source access The linked study records provide the original articles or trial registrations.
Safety evidence Available adverse-event findings and follow-up periods appear in the study notes.

Open a topic for the evidence assessment.

More findings, background and history

What remains unclear

Group assignment, comparators, planned outcomes, effect estimates, adverse events and possible participant overlap are key limits to interpreting the studies.

Human reports are linked; their presence does not establish effectiveness. Several publications can describe the same participants.

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03 / SOURCE RECORDS

Linked sources

Explore the research map and unresolved leads ↗

2017 · Noofen in chronic cerebrovascular insufficiency with fatigueFatigue score: MFI-20 fell from 67.3±4.7 to 41.4±3.1 in the Noofen arm (within-arm p<0.001). Authors reported no change in usual care.

2017Human comparative studyRussian source · see review scope

Noofen in chronic cerebrovascular insufficiency with fatigue

O. V. Vorobieva; V. V. Rusaya · S. S. Korsakov Journal of Neurology and Psychiatry, 117(11), pp. 31–36

MFI-20 fell from 67.3±4.7 to 41.4±3.1 in the Noofen arm (within-arm p<0.001). Authors reported no change in usual care.

Results and tables

Reported findings and study design

Reported findings

Six-week comparison. The authors report random assignment to oral phenibut hydrochloride 500 mg twice daily plus standard care, or standard care alone. The main measure was the MFI-20 fatigue score.

Dose, route and schedule

Six-week comparison. The authors report random assignment to oral phenibut hydrochloride 500 mg twice daily plus standard care, or standard care alone. The main measure was the MFI-20 fatigue score.

Protocol source ↗ · Original source

Results · Original Russian-language source
Measure	Result	Comparison, timing and statistics
Fatigue score	MFI-20 fell from 67.3±4.7 to 41.4±3.1 in the Noofen arm (within-arm p<0.001). Authors reported no change in usual care.
Participants with 30–50% lower fatigue scores	25/33 (75.8%) with add-on Noofen versus 5/20 (25%) with usual care.

No placebo or masking is described. Chronic cerebral ischemia was required for inclusion. The trial measured fatigue in that population.

Source for these results ↗ · Reviewed 2026-11-12

Population / setting: 53 people with chronic cerebral ischemia, fatigue and anxiety, 33 add-on Noofen and 20 usual care
Source reviewed: Six-week comparison. The authors report random assignment to oral phenibut hydrochloride 500 mg twice daily plus standard care, or standard care alone. The main measure was the MFI-20 fatigue score.

Study limitations

No placebo or masking is described. Chronic cerebral ischemia was required for inclusion. The trial measured fatigue in that population.

Reviewed 2026-11-12.

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Research collection curated by @PepMariner · editorial standards. Send a source correction ↗

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