[Multicomponent antithrombotic effect of the neuroprotective prolyl dipeptide GVS-111 and its major metabolite cyclo-L-prolylglycine].
Ostrovskaia RU, Liapina LA, Pastorova VE, Mirzoev TKh, Gudasheva TA, Seredenin SB, Ashmarin IP · 2002 · Eksperimental'naia i klinicheskaia farmakologiia (2002); PMID 12109290
Study data at a glance
- Participants or experimental model
- In-vivo GVS-111 experiments and in-vitro coagulation assays
- Reported results
- GVS-111 altered coagulation and fibrinolysis in experimental work. In-vitro CPG also showed antiaggregant activity; concentrations extending to 10⁻¹⁰ M were reported.
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- The in-vivo regimen was for GVS-111, not CPG. Laboratory coagulation findings do not establish stroke prevention, bleeding safety or a human dose.
- Indexed abstract checked; complete methods, tables and independent replication have not been appraised.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Indexed abstract checked
Source access and review scope
Original publication metadata and indexed abstract checked via Europe PMC; no full-text appraisal.
Recorded source-check date: 2026-10-17. This date does not imply a completed systematic review.
Citation and original source
Original source: Ostrovskaia RU, Liapina LA, Pastorova VE, Mirzoev TKh, Gudasheva TA, Seredenin SB, Ashmarin IP. [Multicomponent antithrombotic effect of the neuroprotective prolyl dipeptide GVS-111 and its major metabolite cyclo-L-prolylglycine]. Eksperimental'naia i klinicheskaia farmakologiia (2002); PMID 12109290 2002.
Molekul research summary: https://molekul.io/research/oct17-12109290. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entryRelated compound profiles
CPG & GZK-111
A grouped record for endogenous cyclo(Pro-Gly), its experimental linear precursor GZK-111 and the connection to Noopept metabolism.
Noopept
A defined synthetic dipeptide derivative connecting nootropic research with experimental environmental adaptation. Human chamber studies, clinical EEG reports and preclinical mechanisms address different questions; none establishes safe hazardous-work use.