[Effect of tripeptide Pro-Gly-Pro on rat brain transcriptome in focal ischemia].
Medvedeva EV, Dmitrieva VG, Povarova OV, Limborskaia SA, Skvortsova VI, Miasoedov NF, Dergunova LV · 2014 · Molekuliarnaia biologiia; 2014
Study findings
PGP altered expression of 29 genes at three hours and 57 at 24 hours; immune-response genes were predominantly downregulated at the later time point.
- Population and setting
- Rat cortical tissue at 3 and 24 hours after permanent focal ischemia
- Evidence type
- Animal / experimental
- Source language
- rus
- Title source
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
Study limitations
- PGP was tested separately; results cannot be assigned wholesale to Semax or Selank.
- Gene-expression endpoints do not establish clinical stroke efficacy.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Source access and review scope
Indexed primary-publication abstract checked; full methods not appraised.
Recorded source-check date: 2026-10-11. This date does not imply a completed systematic review.
Citation and original source
Original source: Medvedeva EV, Dmitrieva VG, Povarova OV, Limborskaia SA, Skvortsova VI, Miasoedov NF, Dergunova LV. [Effect of tripeptide Pro-Gly-Pro on rat brain transcriptome in focal ischemia]. Molekuliarnaia biologiia; 2014 2014.
Molekul research summary: https://molekul.io/research/oct11-25850296. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry